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PAF1 and KMT2A
Number of citations of the paper that reports this interaction (PubMedID
20541477
)
54
Data Source:
BioGRID
(genetic interference, affinity chromatography technology, affinity chromatography technology, pull down)
PAF1
KMT2A
Description
PAF1 component of Paf1/RNA polymerase II complex
lysine methyltransferase 2A
Image
GO Annotations
Cellular Component
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Cdc73/Paf1 Complex
Nucleus
Nucleoplasm
Cytosol
Histone Methyltransferase Complex
MLL1/2 Complex
MLL1 Complex
Molecular Function
RNA Polymerase II Complex Binding
Chromatin Binding
Protein Binding
DNA Binding
Minor Groove Of Adenine-thymine-rich DNA Binding
Chromatin Binding
Protein Binding
Methyltransferase Activity
Zinc Ion Binding
Transferase Activity
Histone H3K4 Methyltransferase Activity
Identical Protein Binding
Protein Homodimerization Activity
Unmethylated CpG Binding
Metal Ion Binding
Protein-cysteine Methyltransferase Activity
Histone H3K4 Monomethyltransferase Activity
Histone H3K4 Trimethyltransferase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Endodermal Cell Fate Commitment
Transcription Elongation By RNA Polymerase II
Wnt Signaling Pathway
Stem Cell Population Maintenance
MRNA 3'-end Processing
Protein Localization To Nucleus
Negative Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Lipopolysaccharide
Positive Regulation Of Cell Cycle G1/S Phase Transition
Immune System Process
Chromatin Organization
Regulation Of DNA-templated Transcription
Apoptotic Process
Visual Learning
Response To Light Stimulus
Post-embryonic Development
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Methylation
Circadian Regulation Of Gene Expression
Embryonic Hemopoiesis
Exploration Behavior
Response To Potassium Ion
Protein Modification Process
Epigenetic Regulation Of Gene Expression
T-helper 2 Cell Differentiation
Transcription Initiation-coupled Chromatin Remodeling
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Fibroblast Proliferation
Negative Regulation Of Fibroblast Proliferation
Regulation Of Short-term Neuronal Synaptic Plasticity
Rhythmic Process
Spleen Development
Homeostasis Of Number Of Cells Within A Tissue
Cognition
Membrane Depolarization
Definitive Hemopoiesis
Protein-containing Complex Assembly
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation
Pathways
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation
E3 ubiquitin ligases ubiquitinate target proteins
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation of granulopoiesis
Formation of WDR5-containing histone-modifying complexes
Regulation of PD-L1(CD274) transcription
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Drugs
Diseases
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Metabolic syndrome (
31589552
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Interacting Genes
17 interacting genes:
CEBPA
ENO1
ERCC6
FXR2
H1-2
H3C1
HSPB1
KAT8
KMT2A
MLLT1
MSL1
MSL2
MSL3
RNF20
SUMO2
TCEA1
TULP3
33 interacting genes:
ASH2L
AVP
BMI1
CBX4
CREBBP
CTNNB1
FASLG
H2AC4
H2BC3
H3-3A
H3C1
H3C14
HCFC1
HCFC2
INS
KAT8
MEN1
MTM1
OXT
PAF1
PLXNB1
PPIE
PPP1R15A
PSIP1
RBBP5
RBM39
RNF2
SBF1
SET
SVIL
TAF9
TASP1
WDR5
Entrez ID
54623
4297
HPRD ID
10140
01162
Ensembl ID
ENSG00000006712
ENSG00000118058
Uniprot IDs
Q8N7H5
A0AA34QVI8
E9PR05
Q03164
PDB IDs
4M6T
5ZYQ
6GMH
6TED
7OOP
7OPC
7OPD
7UNC
7UND
8A3Y
9EGX
9EGY
9EGZ
9EH0
9EH2
2AGH
2J2S
2JYI
2KKF
2KU7
2KYU
2LXS
2LXT
2MSR
2MTN
2W5Y
2W5Z
3EG6
3EMH
3LQH
3LQI
3LQJ
3P4F
3U85
3U88
4ESG
4GQ6
4NW3
5F5E
5F6L
5SVH
6EMQ
6KIU
6KIV
6KIX
6KIZ
6PWV
6PWW
6U9K
6U9M
6U9N
6U9R
6W5I
6W5M
6W5N
7MBM
7MBN
7RZD
7RZJ
7S79
7S7D
7S8A
7S8E
7S8F
7U5V
7W67
7W6A
7W6I
7W6J
7ZEY
7ZEZ
Enriched GO Terms of Interacting Partners
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MSL Complex
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Chromatin Organization
Nucleus
Chromatin Remodeling
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Metabolic Process
Nucleoplasm
Chromatin Binding
Epigenetic Regulation Of Gene Expression
Positive Regulation Of DNA-templated Transcription Initiation
Regulation Of DNA-templated Transcription Initiation
DNA Binding
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription By RNA Polymerase II
Transcription Elongation Factor Complex
Nucleolus
NuA4 Histone Acetyltransferase Complex
MLL1 Complex
Regulation Of Transcription By RNA Polymerase II
Embryonic Organ Development
Chromosome
Protein Homodimerization Activity
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Protein Kinase C Signaling
Histone H2B Ubiquitin Ligase Activity
Histone H2B C-terminal K Residue Ubiquitin Ligase Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Positive Regulation Of Proteolysis
Transcription Initiation-coupled Chromatin Remodeling
Positive Regulation Of Protein Metabolic Process
DNA-templated Transcription Elongation
Positive Regulation Of Gene Expression, Epigenetic
Cerebellar Purkinje Cell Layer Maturation
Response To Vitamin B2
C/EBP Complex
MLL1 Complex
Chromatin Remodeling
MLL1/2 Complex
Chromatin Organization
Histone Methyltransferase Complex
Set1C/COMPASS Complex
Epigenetic Regulation Of Gene Expression
Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Chromatin Binding
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Transcription Initiation-coupled Chromatin Remodeling
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Biosynthetic Process
Histone Acetyltransferase Complex
NSL Complex
Structural Constituent Of Chromatin
Negative Regulation Of DNA-templated Transcription
Nucleoplasm
MLL3/4 Complex
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Neurohypophyseal Hormone Activity
DNA-binding Transcription Factor Binding
Negative Regulation Of RNA Metabolic Process
Transcription Coactivator Activity
Nucleosome Assembly
Protein-DNA Complex Assembly
PRC1 Complex
Nucleosome
Euchromatin
RING-like Zinc Finger Domain Binding
Nucleosome Organization
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Heterodimerization Activity
Maternal Aggressive Behavior
Positive Regulation Of Macromolecule Biosynthetic Process
PcG Protein Complex
Positive Regulation Of Gene Expression
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Histone Acetyltransferase Activity
Positive Regulation Of Metabolic Process
Cell Development
Regulation Of Cell Cycle
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