PAF1 and MSL2

Number of citations of the paper that reports this interaction (PubMedID 24837678)
66

Data Source:
BioGRID (pull down)

		PAF1	MSL2
Description		PAF1 component of Paf1/RNA polymerase II complex	MSL complex subunit 2
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Membrane Cdc73/Paf1 Complex	Chromatin Nucleus Nucleoplasm Chromosome MSL Complex
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Promoter-enhancer Loop Anchoring Activity Histone H2B Ubiquitin Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance MRNA 3'-end Processing Protein Localization To Nucleus Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition	Chromatin Organization Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	HATs acetylate histones
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Blood urea nitrogen levels ( 31152163) C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778 33020668) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 23969696) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31217584) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 29483656 28991256 25056061) Serum alkaline phosphatase levels ( 33339817 33547301) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		17 interacting genes: CEBPA ENO1 ERCC6 FXR2 H1-2 H3C1 HSPB1 KAT8 KMT2A MLLT1 MSL1 MSL2 MSL3 RNF20 SUMO2 TCEA1 TULP3	14 interacting genes: APOBEC3B H2AC18 H2AC20 H2BC21 H3C14 H4C1 PAF1 TP53 TRIM8 UBE2D3 VHL YWHAE YWHAG YWHAZ
Entrez ID		54623	55167
HPRD ID		10140	08550
Ensembl ID		ENSG00000006712	ENSG00000174579
Uniprot IDs		Q8N7H5	Q9HCI7
PDB IDs		4M6T 5ZYQ 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2	4B7Y 4B86
Enriched GO Terms of Interacting Partners?		MSL Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Chromatin Organization Nucleus Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Chromatin Binding Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation DNA Binding Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Transcription Elongation Factor Complex Nucleolus NuA4 Histone Acetyltransferase Complex MLL1 Complex Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Chromosome Protein Homodimerization Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Kinase C Signaling Histone H2B Ubiquitin Ligase Activity Histone H2B C-terminal K Residue Ubiquitin Ligase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Proteolysis Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Protein Metabolic Process DNA-templated Transcription Elongation Positive Regulation Of Gene Expression, Epigenetic Cerebellar Purkinje Cell Layer Maturation Response To Vitamin B2 C/EBP Complex	Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Sequestering Activity Chromatin Remodeling Cellular Response To Glucose Starvation Negative Regulation Of Macromolecule Metabolic Process Phosphoserine Residue Binding Extracellular Exosome Chromosome Negative Regulation Of Metabolic Process Negative Regulation Of TORC1 Signaling Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of TOR Signaling Negative Regulation Of RNA Metabolic Process Protein Polyubiquitination Regulation Of TORC1 Signaling Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Protein Ubiquitination Protein Localization To Organelle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleosome Organization Protein Modification By Small Protein Conjugation Protein K6-linked Ubiquitination Regulation Of Protein Stability Negative Regulation Of Gene Expression Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TOR Signaling Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Response To Stress Negative Regulation Of DNA-templated Transcription Protein Localization To Nucleus Cellular Response To Starvation Post-translational Protein Modification Protein K11-linked Ubiquitination Protein-DNA Complex Assembly Chromatin Binding Proteasomal Protein Catabolic Process Protein Targeting Negative Regulation Of Signal Transduction Regulation Of Protein Localization Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition
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