PAF1 and MSL3

Number of citations of the paper that reports this interaction (PubMedID 24837678)
66

Data Source:
BioGRID (pull down)

		PAF1	MSL3
Description		PAF1 component of Paf1/RNA polymerase II complex	MSL complex subunit 3
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Membrane Cdc73/Paf1 Complex	Nucleus Nucleoplasm NuA4 Histone Acetyltransferase Complex MSL Complex
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding	DNA Binding Protein Binding Histone H4K16ac Reader Activity Histone Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance MRNA 3'-end Processing Protein Localization To Nucleus Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition	Chromatin Organization Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	HATs acetylate histones
Drugs
Diseases
GWAS
Interacting Genes		17 interacting genes: CEBPA ENO1 ERCC6 FXR2 H1-2 H3C1 HSPB1 KAT8 KMT2A MLLT1 MSL1 MSL2 MSL3 RNF20 SUMO2 TCEA1 TULP3	7 interacting genes: APP CDK6 H3-4 H3C1 H4C1 H4C16 PAF1
Entrez ID		54623	10943
HPRD ID		10140	05344
Ensembl ID		ENSG00000006712	ENSG00000005302
Uniprot IDs		Q8N7H5	Q8N5Y2
PDB IDs		4M6T 5ZYQ 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2	2Y0N 3OA6 3OB9
Enriched GO Terms of Interacting Partners?		MSL Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Chromatin Organization Nucleus Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Chromatin Binding Epigenetic Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation DNA Binding Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Transcription Elongation Factor Complex Nucleolus NuA4 Histone Acetyltransferase Complex MLL1 Complex Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Chromosome Protein Homodimerization Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Kinase C Signaling Histone H2B Ubiquitin Ligase Activity Histone H2B C-terminal K Residue Ubiquitin Ligase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Proteolysis Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Protein Metabolic Process DNA-templated Transcription Elongation Positive Regulation Of Gene Expression, Epigenetic Cerebellar Purkinje Cell Layer Maturation Response To Vitamin B2 C/EBP Complex	Protein Heterodimerization Activity Negative Regulation Of Myeloid Cell Differentiation Nucleosome Nucleosome Assembly Structural Constituent Of Chromatin Nucleosome Organization Protein-DNA Complex Assembly Regulation Of Myeloid Cell Differentiation Chromatin Remodeling Regulation Of Cell Differentiation Chromatin Organization Regulation Of Hemopoiesis Telomere Organization CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Protein-containing Complex Assembly Chromosome, Telomeric Region Regulation Of Developmental Process Protein-containing Complex Organization Negative Regulation Of Cell Differentiation Chromosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Regulation Of Immune System Process Protein-containing Complex Regulation Of Cell Development Protein Localization To Chromatin Chromosome Organization Glial Cell Development Negative Regulation Of Developmental Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cyclin D2-CDK6 Complex Extracellular Exosome DNA Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Nucleoplasm Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Localization To Chromosome Cellular Component Assembly Notch Signaling Pathway Nucleus
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