PAF1 and MSL3

Number of citations of the paper that reports this interaction (PMID 24837678)
0

Data Source:
BioGRID (pull down)

		PAF1	MSL3
Gene Name		Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	male-specific lethal 3 homolog (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Cdc73/Paf1 Complex	Nucleus Nucleoplasm MSL Complex
	Molecular Function	RNA Polymerase II Core Binding Chromatin Binding Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Methylated Histone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide	Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Histone H4-K16 Acetylation
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: FXR2 HIST1H1C HIST1H3A KAT8 KMT2A LEO1 MLLT1 MSL1 MSL2 MSL3 RNF20 TCEA1	8 interactors: APP CDK6 HIST1H3A HIST1H4A HIST3H3 HIST4H4 KAT8 PAF1
Entrez ID		54623	10943
HPRD ID		10140	05344
Ensembl ID		ENSG00000006712	ENSG00000005302
Uniprot IDs		M0QX35 Q8N7H5	B7Z227 Q8N5Y2
PDB IDs		4M6T	2Y0N 3OA6 3OB9
Enriched GO Terms of Interacting Partners?		Histone H4-K16 Acetylation Chromatin Organization Histone H4 Acetylation Chromosome Organization Histone Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Chromatin Modification Peptidyl-lysine Modification Organelle Organization Histone H2B Ubiquitination Histone Monoubiquitination Peptidyl-amino Acid Modification Regulation Of Gene Expression Histone Ubiquitination Positive Regulation Of Histone Methylation Protein Monoubiquitination Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Histone Methylation Regulation Of DNA-templated Transcription, Elongation Cellular Protein Modification Process Regulation Of RNA Metabolic Process DNA Methylation Transcription, DNA-templated Positive Regulation Of Cellular Response To Drug Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression RNA Biosynthetic Process Positive Regulation Of Histone Modification Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process DNA Modification Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Protein Metabolic Process Nucleosome Assembly Regulation Of Histone Modification Chromatin Assembly Nucleosome Organization Regulation Of Metabolic Process Regulation Of Response To Drug	DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Negative Regulation Of Myeloid Cell Differentiation Chromatin Silencing At RDNA Chromatin Silencing Chromosome Organization Regulation Of Myeloid Cell Differentiation Histone H4-K20 Demethylation DNA Methylation Negative Regulation Of Megakaryocyte Differentiation Chromatin Organization Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance DNA Modification Negative Regulation Of Immune System Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Gene Silencing Histone Modification Nucleosome Assembly Chromatin Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nucleosome Organization Negative Regulation Of RNA Biosynthetic Process Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Megakaryocyte Differentiation DNA Packaging Negative Regulation Of Gene Expression Chromatin Modification Negative Regulation Of Biosynthetic Process Homeostatic Process CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic MRNA Polyadenylation Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Regulation Of Cell Differentiation Histone Demethylation RNA Polyadenylation Nucleobase-containing Compound Metabolic Process Protein Demethylation DNA Conformation Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression
Tagcloud ?		ablates ada2 ap2 apicomplexa apicomplexan dd ddhagcn5b destabilization dispensable e703g gcn5a gcn5b gondii indispensable invertebrates kat kats leo1 lytic parasite parasites phylum possessing proteomics protozoan redundant rrm tfiid toxoplasma	achieve analyze chip chromodomain chromodomains compensation counterparts disruption dosage drosophila entry flanking h3k36me3 lethal marked melanogaster mutants nucleosomal nucleosomes preferential respective retain similarly spread spreading targeting trimethylation upregulates
Tagcloud (Difference) ?		ablates ada2 ap2 apicomplexa apicomplexan dd ddhagcn5b destabilization dispensable e703g gcn5a gcn5b gondii indispensable invertebrates kat kats leo1 lytic parasite parasites phylum possessing proteomics protozoan redundant rrm tfiid toxoplasma	achieve analyze chip chromodomain chromodomains compensation counterparts disruption dosage drosophila entry flanking h3k36me3 lethal marked melanogaster mutants nucleosomal nucleosomes preferential respective retain similarly spread spreading targeting trimethylation upregulates
Tagcloud (Intersection) ?