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POU5F1 and HMGB1
Number of citations of the paper that reports this interaction (PubMedID
11099378
)
0
Data Source:
HPRD
(in vitro, in vivo)
POU5F1
HMGB1
Description
POU class 5 homeobox 1
high mobility group box 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Condensed Chromosome
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Endosome
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Plasma Membrane
Cell Surface
Membrane
Transcription Repressor Complex
Secretory Granule Lumen
Alphav-beta3 Integrin-HMGB1 Complex
Neuron Projection
Ficolin-1-rich Granule Lumen
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
Protein Binding
Ubiquitin Protein Ligase Binding
MiRNA Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Transcription Cis-regulatory Region Binding
Lipopolysaccharide Binding
Phosphatidylserine Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Cytokine Activity
Integrin Binding
Protein Binding
Lipid Binding
DNA Binding, Bending
Calcium-dependent Protein Kinase Regulator Activity
Lyase Activity
C-X-C Chemokine Binding
Protein Kinase Activator Activity
Chemoattractant Activity
Receptor Ligand Activity
RAGE Receptor Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA Polymerase Binding
Supercoiled DNA Binding
DNA-binding Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Endodermal Cell Fate Specification
Blastocyst Development
Heart Induction
Endodermal-mesodermal Cell Signaling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Response To Wounding
Anatomical Structure Morphogenesis
Regulation Of Asymmetric Cell Division
Regulation Of Gene Expression
BMP Signaling Pathway
Somatic Stem Cell Population Maintenance
Positive Regulation Of Transcription By RNA Polymerase II
Cell Fate Commitment Involved In Formation Of Primary Germ Layer
Cardiac Cell Fate Determination
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of MiRNA Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Eye Development
Myeloid Dendritic Cell Activation
Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Activation Of Innate Immune Response
Adaptive Immune Response
Plasmacytoid Dendritic Cell Activation
Macrophage Activation Involved In Immune Response
Myeloid Progenitor Cell Differentiation
Immune System Process
Dendritic Cell Chemotaxis
Inflammatory Response To Antigenic Stimulus
Regulation Of Tolerance Induction
Regulation Of T Cell Mediated Immune Response To Tumor Cell
Glycogen Catabolic Process
DNA Metabolic Process
DNA Topological Change
DNA Repair
Base-excision Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Chromatin Organization
Chromatin Remodeling
Transcription By RNA Polymerase II
Autophagy
Chemotaxis
Inflammatory Response
Immune Response
DNA Damage Response
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Autophagy
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Myeloid Cell Differentiation
Lung Development
Neuron Projection Development
Heterochromatin Formation
Regulation Of Restriction Endodeoxyribonuclease Activity
DNA Geometric Change
Positive Regulation Of Mismatch Repair
Negative Regulation Of Type II Interferon Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
V(D)J Recombination
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 9 Signaling Pathway
T-helper 1 Cell Activation
Endothelial Cell Chemotaxis
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
T-helper 1 Cell Differentiation
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Cell Differentiation
Positive Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Glycogen Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Viral Entry Into Host Cell
Cell Development
Regulation Of Viral Process
Positive Chemotaxis
Regulation Of DNA Metabolic Process
Response To Glucocorticoid
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Positive Regulation Of Monocyte Chemotaxis
Positive Regulation Of Wound Healing
Neutrophil Clearance
Cellular Response To Interleukin-7
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Sprouting Angiogenesis
Regulation Of Hemopoiesis
Positive Regulation Of Myeloid Progenitor Cell Differentiation
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Apoptotic Cell Clearance
Regulation Of Nucleotide-excision Repair
Positive Regulation Of Dendritic Cell Differentiation
Pathways
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation of pluripotent stem cells
Germ layer formation at gastrulation
Formation of the anterior neural plate
Specification of primordial germ cells
Specification of the neural plate border
ER-Phagosome pathway
Apoptosis induced DNA fragmentation
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
TAK1-dependent IKK and NF-kappa-B activation
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Pyroptosis
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Drugs
Chloroquine
Ethyl pyruvate
Diseases
GWAS
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Cold sores (
28928442
)
Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) (
21801394
)
Epstein-Barr virus copy number in lymphoblastoid cell lines (
28654678
)
Hip circumference adjusted for BMI (
34021172
)
Inflammatory bowel disease (
28067908
)
Lung cancer (
31577861
)
Lymphocyte count (
27863252
)
Malaria (
31844061
)
Multiple myeloma (
23955597
)
Night sleep phenotypes (
27126917
)
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) (
21912425
)
Type 2 diabetes (
28869590
30718926
24509480
)
Ulcerative colitis (
28067908
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Adult body size (
32376654
)
Apolipoprotein A1 levels (
32203549
)
Blood osmolality (transformed sodium) (
28360221
)
Carotid plaque burden (
28282560
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Hippocampal volume (
21116278
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Rapid response to perioperative phenylephrine (change in mean arterial pressure) (
33168928
)
Red blood cell count (
32888494
)
Triglyceride levels (
32203549
32154731
)
Type 2 diabetes (
30297969
)
Urate levels (
31578528
)
Interacting Genes
15 interacting genes:
AR
CFTR
ETS2
EWSR1
FOXD3
HMGB1
HMGB2
ITCH
LRRK2
MNAT1
NR0B1
SOX10
SOX2
SOX8
WDR5
132 interacting genes:
ACBD3
AGER
AGTRAP
AKIP1
AR
ATF7IP
ATOH1
C1QA
C1QBP
C3
CASP3
CCAR1
CCNDBP1
CDK1
CEBPA
CEBPB
CREBBP
CRMP1
CSNK1A1
CTCF
CTNNBL1
CUX1
DAG1
DLAT
DNAAF2
DNM2
DNMT1
DUX4
DYNC2I1
EIF1
ENAH
EP300
ERF
ERG28
FIP1L1
FOS
FOXA3
FOXC1
GOLM1
GTF2A1
HDAC1
HDLBP
HES1
HMGA1
HNRNPK
HNRNPU
HOXA10
HOXB1
HOXB3
HOXC6
HOXD10
HOXD11
HOXD3
HOXD8
HOXD9
HPF1
HR
HSPA5
IRF2
KRT7
LRIF1
MALAT1
MAP1B
MAPKAPK5
MECP2
MIEN1
MNAT1
MNT
MT2A
NCAN
NEUROD6
NEXN
NFKB1
NR3C1
PCOLCE
PGR
PLAT
PLG
POU5F1
PPP2R3A
PRKCA
PRKDC
PSEN1
PSMA7
PTPN2
PTPRZ1
RAD23B
RAG1
RASAL2
RASSF4
RB1
RBPJ
RELA
RFX1
RPL29
RPS12
RPS20
RSF1
SIX5
SOX18
SPIN1
SPINT1
SRSF3
STUB1
TAF1
TAF3
TBP
TERF2
TERF2IP
TFE3
TGIF1
TGM2
TGM3
TLE1
TLE2
TLE5
TLR2
TLR4
TP53
TP73
UBC
UBE2E3
UBE2I
UBXN1
UHRF2
UNC119
USP12
WNK4
YY1
ZFP36
ZNF24
ZNF428
Entrez ID
5460
3146
HPRD ID
01252
01228
Ensembl ID
ENSG00000204531
ENSG00000189403
Uniprot IDs
D2IYK3
F2Z381
M1S623
Q01860
B7Z965
P09429
Q5T7C4
PDB IDs
6T90
6YOV
7U0G
7U0I
8G87
8G88
8G8B
8G8E
8G8G
8OTS
8SPS
8SPU
2LY4
2RTU
2YRQ
6CG0
6CIJ
6CIK
6CIL
6CIM
6OEM
6OEN
6OEO
8I9M
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of DNA-templated Transcription
Nucleoplasm
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Animal Organ Development
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of RNA Metabolic Process
Chromatin
Regulation Of Macromolecule Metabolic Process
Male Gonad Development
Transcription Cis-regulatory Region Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Developmental Process
Positive Regulation Of Macromolecule Metabolic Process
Gonad Development
Developmental Process
Positive Regulation Of Macromolecule Biosynthetic Process
Nucleus
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Supercoiled DNA Binding
Positive Regulation Of Biosynthetic Process
DNA-binding Transcription Factor Activity
Positive Regulation Of Metabolic Process
Regulation Of Morphogenesis Of A Branching Structure
DNA-binding Transcription Factor Binding
Regulation Of Cell Differentiation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Reproductive Structure Development
DNA Geometric Change
Glial Cell Fate Commitment
Chromatin
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Nucleus
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Transcription Regulator Complex
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Sequence-specific DNA Binding
Regionalization
Anterior/posterior Pattern Specification
Transcription Cis-regulatory Region Binding
Macromolecule Metabolic Process
Sequence-specific Double-stranded DNA Binding
Pattern Specification Process
Positive Regulation Of Developmental Process
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Chromatin Binding
Macromolecule Biosynthetic Process
Anatomical Structure Morphogenesis
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Tagcloud (Intersection)
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