POU5F1 and SOX8

Number of citations of the paper that reports this interaction (PMID 16582099)
41

Data Source:
HPRD (in vitro)

		POU5F1	SOX8
Gene Name		POU class 5 homeobox 1	SRY (sex determining region Y)-box 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol	Nucleus Cytoplasm Nuclear Transcription Factor Complex
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding MiRNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Transcription Factor Binding Protein Heterodimerization Activity
	Biological Process	Endodermal Cell Fate Specification Blastocyst Development BMP Signaling Pathway Involved In Heart Induction Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Regulation Of Gene Expression Somatic Stem Cell Maintenance Positive Regulation Of Catenin Import Into Nucleus MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of SMAD Protein Import Into Nucleus Cell Fate Commitment Involved In Formation Of Primary Germ Layer Cardiac Cell Fate Determination Negative Regulation Of Gene Silencing By MiRNA Regulation Of Heart Induction By Regulation Of Canonical Wnt Signaling Pathway Regulation Of Methylation-dependent Chromatin Silencing	Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways		Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS		Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425 21801394)	Multiple sclerosis ( 21833088)
Protein-Protein Interactions		14 interactors: AR ETS2 EWSR1 FOXD3 HMGB1 HMGB2 ITCH MNAT1 NR0B1 SOX10 SOX2 SOX8 WDR5 WWP2	18 interactors: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1
Entrez ID		5460	30812
HPRD ID		01252	16175
Ensembl ID		ENSG00000204531	ENSG00000005513
Uniprot IDs		D2IYK3 M1S623 Q01860	P57073
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Reproductive Structure Development Reproductive System Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Apoptotic Process Cellular Nitrogen Compound Metabolic Process Sex Differentiation Regulation Of Cell Death System Development RNA Metabolic Process Nitrogen Compound Metabolic Process Developmental Process Involved In Reproduction Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Base-excision Repair, DNA Ligation Cellular Macromolecule Biosynthetic Process Male Sex Differentiation Positive Regulation Of Cell Proliferation Multicellular Organismal Development Macromolecule Biosynthetic Process Anatomical Structure Development Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Proliferation	Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Regulation Of Gene Expression RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process System Development Cell Differentiation Tissue Development Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gland Development Developmental Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Liver Development Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process Embryonic Organ Development Positive Regulation By Host Of Viral Transcription Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Myeloid Cell Differentiation Heart Development Endoderm Development
Tagcloud ?		catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely jmjd1c nanog newly nucleosome oct4 opposes pluripotency recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby	adipocytes anabolic anesthesia cattle chronically coexpression coincident covering dorsi false implant intramuscular ld longissimus mid myofiber neuropeptide oxt oxtr oxytocin positives profiled reflecting revalor satellite steroid trenbolone twitch unexpectedly
Tagcloud (Difference) ?		catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely jmjd1c nanog newly nucleosome oct4 opposes pluripotency recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby	adipocytes anabolic anesthesia cattle chronically coexpression coincident covering dorsi false implant intramuscular ld longissimus mid myofiber neuropeptide oxt oxtr oxytocin positives profiled reflecting revalor satellite steroid trenbolone twitch unexpectedly
Tagcloud (Intersection) ?