POU5F1 and MNAT1

Number of citations of the paper that reports this interaction (PMID 9368058)
15

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		POU5F1	MNAT1
Gene Name		POU class 5 homeobox 1	MNAT CDK-activating kinase assembly factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol	Nucleoplasm Holo TFIIH Complex Cytoplasm
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding MiRNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding	Protein Binding DNA-dependent ATPase Activity Zinc Ion Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Protein N-terminus Binding
	Biological Process	Endodermal Cell Fate Specification Blastocyst Development BMP Signaling Pathway Involved In Heart Induction Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Regulation Of Gene Expression Somatic Stem Cell Maintenance Positive Regulation Of Catenin Import Into Nucleus MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of SMAD Protein Import Into Nucleus Cell Fate Commitment Involved In Formation Of Primary Germ Layer Cardiac Cell Fate Determination Negative Regulation Of Gene Silencing By MiRNA Regulation Of Heart Induction By Regulation Of Canonical Wnt Signaling Pathway Regulation Of Methylation-dependent Chromatin Silencing	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Complex Assembly Protein Phosphorylation Adult Heart Development Cell Proliferation Gene Expression Viral Process Ventricular System Development Regulation Of Gene Expression, Epigenetic Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Viral Transcription Response To Calcium Ion
Pathways		Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Tat-mediated elongation of the HIV-1 transcript Cyclin E associated events during G1/S transition Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression G1/S Transition Mitotic G1-G1/S phases S Phase Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases Transcription of the HIV genome Nucleotide Excision Repair RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation HIV Infection RNA Polymerase I Promoter Clearance Formation of the Early Elongation Complex G2/M Transition RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Cyclin A/B1 associated events during G2/M transition RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER RNA Polymerase I Transcription mRNA Capping RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination G1 Phase Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic Cyclin D associated events in G1 Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425 21801394)	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		14 interactors: AR ETS2 EWSR1 FOXD3 HMGB1 HMGB2 ITCH MNAT1 NR0B1 SOX10 SOX2 SOX8 WDR5 WWP2	42 interactors: BRCA1 CCNH CDK7 COPS6 CTD DMAP1 E2F1 EEF1A1 ERCC3 ESR1 GTF2E2 HPS6 LRIF1 MBP MCM7 MDM4 MKRN3 MTA1 NGFRAP1 NKX3-1 POLR2A POU2F1 POU2F2 POU5F1 RB1 RBM48 RNF32 RNF41 RNF7 SUPT5H TP53 TRIM17 TRIM2 TRIM21 TRIM26 TRIM31 TRIM34 TRIM39 TRIM5 TRIM9 TRIML1 USP2
Entrez ID		5460	4331
HPRD ID		01252	04042
Ensembl ID		ENSG00000204531	ENSG00000020426
Uniprot IDs		D2IYK3 M1S623 Q01860	P51948
PDB IDs			1G25
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Reproductive Structure Development Reproductive System Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Apoptotic Process Cellular Nitrogen Compound Metabolic Process Sex Differentiation Regulation Of Cell Death System Development RNA Metabolic Process Nitrogen Compound Metabolic Process Developmental Process Involved In Reproduction Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Base-excision Repair, DNA Ligation Cellular Macromolecule Biosynthetic Process Male Sex Differentiation Positive Regulation Of Cell Proliferation Multicellular Organismal Development Macromolecule Biosynthetic Process Anatomical Structure Development Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Proliferation	Regulation Of Transcription, DNA-templated Regulation Of Viral Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Viral Transcription Protein Ubiquitination Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Modification By Small Protein Conjugation Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Positive Regulation Of Viral Process 7-methylguanosine RNA Capping Transcription, DNA-templated DNA-templated Transcription, Elongation Regulation Of Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Stress Positive Regulation Of Viral Transcription Viral Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To DNA Damage Stimulus Regulation Of Viral Release From Host Cell Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Cycle Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Response To Stimulus Cellular Response To Stress Nucleotide-excision Repair Androgen Receptor Signaling Pathway RNA Metabolic Process Cellular Protein Modification Process Transcription-coupled Nucleotide-excision Repair
Tagcloud ?		catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely jmjd1c nanog newly nucleosome oct4 opposes pluripotency recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby	affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a ube2v2
Tagcloud (Difference) ?		catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely jmjd1c nanog newly nucleosome oct4 opposes pluripotency recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby	affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a ube2v2
Tagcloud (Intersection) ?