DLL4 and NOTCH4

Number of citations of the paper that reports this interaction (PMID 12814948)
22

Data Source:
HPRD (in vitro, in vivo)

		DLL4	NOTCH4
Gene Name		delta-like 4 (Drosophila)	notch 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Notch Binding Calcium Ion Binding	Receptor Activity Calcium Ion Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Patterning Of Blood Vessels Blood Vessel Remodeling Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Pericardium Morphogenesis Signal Transduction Notch Signaling Pathway Notch Receptor Processing Visual Perception Blood Circulation Negative Regulation Of Cell Proliferation Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dorsal Aorta Morphogenesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Neurogenesis Ventral Spinal Cord Interneuron Fate Commitment Regulation Of Neural Retina Development Notch Signaling Involved In Heart Development Blood Vessel Lumenization Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Neural Precursor Cell Proliferation	Patterning Of Blood Vessels Cell Fate Determination Morphogenesis Of A Branching Structure Endothelial Cell Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Transcription Of Notch Receptor Target Embryo Development Gene Expression Hemopoiesis Cell Differentiation Mammary Gland Development Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Notch-HLH transcription pathway Signaling by NOTCH4 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing
Drugs
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Age-related macular degeneration ( 22694956) Asthma ( 21804548) Circulating myeloperoxidase levels (serum) ( 23620142) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) HIV-1 control ( 20041166) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Schizophrenia ( 19571808 23894747) Systemic lupus erythematosus ( 21408207) Systemic sclerosis ( 21779181)
Protein-Protein Interactions		2 interactors: NOTCH1 NOTCH4	13 interactors: DLL4 EGFL7 FBXW7 MAML1 MAML2 MAML3 PSEN1 PSEN2 RBPJ SMAD2 SMAD3 SMAD4 TCEB1
Entrez ID		54567	4855
HPRD ID		05540	01290
Ensembl ID		ENSG00000128917	ENSG00000204301
Uniprot IDs		Q9NR61	Q99466
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Endothelial Cell Differentiation Notch Receptor Processing Endothelial Cell Differentiation Endothelium Development Notch Signaling Pathway Regulation Of Epithelial Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Development Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation DNA-templated Transcription, Initiation Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Cell Fate Commitment Cardiac Right Atrium Morphogenesis Mitral Valve Formation Vasculogenesis Involved In Coronary Vascular Morphogenesis Angiogenesis Negative Regulation Of Pro-B Cell Differentiation Growth Involved In Heart Morphogenesis Atrioventricular Node Development Coronary Vein Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Epithelial Tube Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Cardiac Right Ventricle Formation Negative Regulation Of Endothelial Cell Chemotaxis Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Photoreceptor Cell Differentiation Blood Vessel Morphogenesis Tube Morphogenesis Regulation Of Pro-B Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Aortic Valve Morphogenesis Cardiac Vascular Smooth Muscle Cell Development Compartment Pattern Specification Regulation Of Extracellular Matrix Assembly Pattern Specification Process Gland Development Mitral Valve Morphogenesis Apoptotic Process Involved In Embryonic Digit Morphogenesis Pericardium Morphogenesis Glomerular Mesangial Cell Development Morphogenesis Of An Epithelium Blood Vessel Development Vasculature Development Mitral Valve Development Coronary Artery Morphogenesis	Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Cardiovascular System Development Tube Development Positive Regulation Of Metabolic Process Pattern Specification Process Regulation Of Transcription From RNA Polymerase II Promoter Heart Development Transcription From RNA Polymerase II Promoter Cell Fate Commitment SMAD Protein Complex Assembly Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Tube Morphogenesis Positive Regulation Of Cellular Metabolic Process Somitogenesis Regulation Of ERBB Signaling Pathway Heart Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Somite Development Anterior/posterior Pattern Specification Notch Receptor Processing Regulation Of Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Pericardium Development Segmentation Blood Vessel Lumenization Organ Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Dorsal/ventral Pattern Formation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Epithelium Development Embryonic Morphogenesis Regulation Of RNA Metabolic Process Tissue Morphogenesis Anatomical Structure Morphogenesis Negative Regulation Of Cell Proliferation Tissue Development Cell Differentiation Embryo Development Positive Regulation Of BMP Signaling Pathway Epithelial Tube Morphogenesis
Tagcloud ?		aiming antiangiogenic ascribed conh2 cys13 cys3 dds definitely desired ec excavated fabricated fadu firstly gd16 grctnfhnfiyicfpd h2n huvec implies intensively matrigel multistep nanomedicine neovasculature np plug ptx targetable urgently	antileukemic antiproliferative apigenin baicalein cdc2 cdk4 cdk6 chrysin division dysregulated dysregulation flavonoids galangin genistein hl illustrated jurkat k562 luteolin naringenin nb4 potencies ppa proteomic scutellarin suppresses u937 ubiquitously xiap
Tagcloud (Difference) ?		aiming antiangiogenic ascribed conh2 cys13 cys3 dds definitely desired ec excavated fabricated fadu firstly gd16 grctnfhnfiyicfpd h2n huvec implies intensively matrigel multistep nanomedicine neovasculature np plug ptx targetable urgently	antileukemic antiproliferative apigenin baicalein cdc2 cdk4 cdk6 chrysin division dysregulated dysregulation flavonoids galangin genistein hl illustrated jurkat k562 luteolin naringenin nb4 potencies ppa proteomic scutellarin suppresses u937 ubiquitously xiap
Tagcloud (Intersection) ?