DLL4

Name	delta like canonical Notch ligand 4
Structure
Novel Interactors	1 novel interactors: PAK6
Interactors	2 interactors: NOTCH1 NOTCH4
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Receptor Ligand Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Branching Involved In Blood Vessel Morphogenesis Blood Vessel Remodeling Aortic Valve Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Pericardium Morphogenesis Cell Communication Signal Transduction Notch Signaling Pathway Nervous System Development Visual Perception Negative Regulation Of Cell Population Proliferation Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation T Cell Differentiation Dorsal Aorta Morphogenesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Animal Organ Development System Development Regulation Of Neurogenesis Ventral Spinal Cord Interneuron Fate Commitment Regulation Of Neural Retina Development Blood Vessel Lumenization Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Neural Precursor Cell Proliferation
Pathways	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus
GWAS	General cognitive ability ( 29844566 ) Intelligence (MTAG) ( 29326435 ) Malaria ( 31844061 ) Metabolite levels ( 23823483 ) Multiple sclerosis ( 31604244 ) Refractive error ( 32231278 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738 )
Entrez ID	54567
HPRD ID	05540
Ensembl ID	ENSG00000128917
Uniprot IDs	Q9NR61
PDB IDs	5MVX
GO Terms Enriched among Interactors ?	Luteolysis Positive Regulation Of Transcription Of Notch Receptor Target Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Cell Adhesion Molecule Production Regulation Of Cell Adhesion Molecule Production Notch Binding Positive Regulation Of Smooth Muscle Cell Differentiation Endothelial Cell Differentiation Regulation Of Endothelial Cell Differentiation Ovulation Cycle Process Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Epithelial To Mesenchymal Transition Mesenchymal Cell Differentiation Notch Signaling Pathway Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Branching Morphogenesis Of An Epithelial Tube Developmental Growth Involved In Morphogenesis Regulation Of Muscle Cell Differentiation Regulation Of Epithelial Cell Differentiation Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Notch Signaling Involved In Heart Development Endocardium Morphogenesis Mitral Valve Formation Positive Regulation Of Aorta Morphogenesis Coronary Vein Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cardiac Right Atrium Morphogenesis MAML1-RBP-Jkappa- ICN1 Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Distal Tubule Development Negative Regulation Of Cell-cell Adhesion Auditory Receptor Cell Fate Commitment Regulation Of Aorta Morphogenesis Growth Involved In Heart Morphogenesis Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Epidermal Cell Fate Specification Anatomical Structure Morphogenesis Retinal Cone Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Pro-B Cell Differentiation Cardiac Right Ventricle Formation