DLL4

Gene Name		delta-like 4 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Notch Binding Calcium Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Patterning Of Blood Vessels Blood Vessel Remodeling Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Pericardium Morphogenesis Signal Transduction Notch Signaling Pathway Notch Receptor Processing Visual Perception Blood Circulation Negative Regulation Of Cell Proliferation Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Dorsal Aorta Morphogenesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Neurogenesis Ventral Spinal Cord Interneuron Fate Commitment Regulation Of Neural Retina Development Notch Signaling Involved In Heart Development Blood Vessel Lumenization Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-protein Interactions		2 interactors: NOTCH1 NOTCH4
Entrez ID		54567
HPRD ID		05540
Ensembl ID		ENSG00000128917
Uniprot IDs		Q9NR61
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Endothelial Cell Differentiation Notch Receptor Processing Endothelial Cell Differentiation Endothelium Development Notch Signaling Pathway Regulation Of Epithelial Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Development Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation DNA-templated Transcription, Initiation Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Cell Fate Commitment Cardiac Right Atrium Morphogenesis Mitral Valve Formation Vasculogenesis Involved In Coronary Vascular Morphogenesis Angiogenesis Negative Regulation Of Pro-B Cell Differentiation Growth Involved In Heart Morphogenesis Atrioventricular Node Development Coronary Vein Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Epithelial Tube Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Cardiac Right Ventricle Formation Negative Regulation Of Endothelial Cell Chemotaxis Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Photoreceptor Cell Differentiation Blood Vessel Morphogenesis Tube Morphogenesis Regulation Of Pro-B Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Aortic Valve Morphogenesis Cardiac Vascular Smooth Muscle Cell Development Compartment Pattern Specification Regulation Of Extracellular Matrix Assembly Pattern Specification Process Gland Development Mitral Valve Morphogenesis Apoptotic Process Involved In Embryonic Digit Morphogenesis Pericardium Morphogenesis Glomerular Mesangial Cell Development Morphogenesis Of An Epithelium Blood Vessel Development Vasculature Development Mitral Valve Development Coronary Artery Morphogenesis
Tagcloud ?		aiming antiangiogenic ascribed conh2 cys13 cys3 dds definitely desired ec excavated fabricated fadu firstly gd16 grctnfhnfiyicfpd h2n huvec implies intensively matrigel multistep nanomedicine neovasculature np plug ptx targetable urgently