NOTCH4 and MSH5

		NOTCH4	MSH5
Description		notch receptor 4	mutS homolog 5
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Membrane	Nucleus
	Molecular Function	Transcription Coactivator Activity Notch Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity	Nucleotide Binding DNA Binding Double-stranded DNA Binding Protein Binding ATP Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Luteolysis Branching Involved In Blood Vessel Morphogenesis Cell Fate Determination Morphogenesis Of A Branching Structure Epithelial To Mesenchymal Transition Endothelial Cell Morphogenesis Vasculature Development Regulation Of DNA-templated Transcription Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Tissue Development Hemopoiesis Cell Differentiation Mammary Gland Development Endothelial Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Regulation Of Developmental Process Positive Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	DNA Repair Mismatch Repair DNA Damage Response Meiosis I Chiasma Assembly Meiotic Cell Cycle
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling	Meiotic recombination
Drugs
Diseases
GWAS		A body shape index ( 34021172) Age-related macular degeneration ( 22694956) Aspartate aminotransferase levels ( 29403010) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Circulating myeloperoxidase levels (serum) ( 23620142) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Colorectal cancer ( 30529582) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Femur bone mineral density x serum urate levels interaction ( 34046847) Food antigen IgG levels ( 24962563) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Joint mobility (Beighton score) ( 27182965) Longevity ( 30294719) Lung cancer ( 31577861 28604730) Lung cancer in ever smokers ( 28604730) Lupus nephritis in systemic lupus erythematosus ( 24925725) Migraine ( 27322543) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Obesity-related traits ( 23251661) Objective response to lithium treatment in bipolar disorder ( 26503763) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 23894747 19571808 30285260) Soluble receptor for advanced glycation end-product levels ( 26083729) Squamous cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 32771030 21408207) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908 24837172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cutaneous lupus erythematosus ( 25827949) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lung cancer ( 18978787) Mastocytosis ( 32752121) Medication use (anilides) ( 31015401) Menopause (age at onset) ( 26414677) Pulse pressure ( 27618448) Systemic lupus erythematosus ( 26316170) Systemic mastocytosis ( 32752121) Systolic blood pressure ( 27618448) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908 24837172)
Interacting Genes		13 interacting genes: DLL4 EGFL7 ELOC FBXW7 MAML1 MAML2 MAML3 PSEN1 PSEN2 RBPJ SMAD2 SMAD3 SMAD4	4 interacting genes: MLH1 MLH3 MSH4 TRIM54
Entrez ID		4855	4439
HPRD ID		01290	04544
Ensembl ID		ENSG00000204301	ENSG00000204410
Uniprot IDs		A0A1U9X983 Q99466	A0A024RCM1 O43196
PDB IDs		7OR3 7OR5 7OR7
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Protein Complex Positive Regulation Of Transcription By RNA Polymerase II Heteromeric SMAD Protein Complex Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regionalization I-SMAD Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Blood Vessel Lumenization Anterior/posterior Pattern Specification Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding MAML1-RBP-Jkappa- ICN1 Complex Activin Responsive Factor Complex SMAD Protein Signal Transduction Paraxial Mesoderm Morphogenesis R-SMAD Binding Regulation Of Notch Signaling Pathway Activin Receptor Signaling Pathway Pattern Specification Process Tissue Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endoderm Development Positive Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Transcription Regulator Complex Epithelial Tube Morphogenesis Embryonic Morphogenesis Regulation Of Gene Expression Mesoderm Morphogenesis Regulation Of Macromolecule Biosynthetic Process Neuron Fate Commitment Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Primary Metabolic Process Negative Regulation Of Ossification Pericardium Development Aspartic Endopeptidase Activity, Intramembrane Cleaving Negative Regulation Of Macromolecule Biosynthetic Process Ventricular Cardiac Muscle Tissue Morphogenesis	Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity Mismatch Repair Reciprocal Meiotic Recombination Chiasma Synaptonemal Complex Condensed Chromosome Homologous Recombination Condensed Nuclear Chromosome Chromosome Organization Involved In Meiotic Cell Cycle Mismatch Repair Complex Homologous Chromosome Pairing At Meiosis DNA Recombination Male Meiotic Nuclear Division Male Germ Cell Nucleus Chromosome Organization Female Gamete Generation Meiosis I Cell Cycle Process Meiotic Nuclear Division Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Recombination Nodule Nuclear Division Reproductive Process DNA Repair Meiotic Cell Cycle Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Alpha-sialidase Activity Male Meiosis Chromosome Segregation MutLalpha Complex DNA Metabolic Process Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Exo-alpha-sialidase Activity Satellite DNA Binding DNA Damage Response Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Luteolysis Positive Regulation Of Isotype Switching To IgA Isotypes Centromeric DNA Binding MutSalpha Complex Binding Regulation Of Mitotic Recombination Positive Regulation Of Transcription Of Notch Receptor Target Female Meiosis I Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Ganglioside Catabolic Process Telomere Localization
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