MAX and UNC45A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MAX	UNC45A
Description		MYC associated factor X	unc-45 myosin chaperone A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Dendrite Protein-DNA Complex Cell Projection Mad-Max Complex MLL1 Complex Myc-Max Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Cytoplasm Golgi Apparatus Cytosol Nuclear Speck Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Cadherin Binding Hsp90 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Protein Folding Muscle Organ Development Cell Differentiation
Pathways		Transcription of E2F targets under negative control by DREAM complex Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Anthropometric traits ( 19260139) Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Blood trace element (Zn levels) ( 23720494) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		43 interacting genes: BANP CASP5 CASP7 CLIP2 COPS5 CSNK2A1 CUX1 EP300 EPAS1 FTH1 FUS GABBR1 HIF1A MAD1L1 MAPK14 MGA MNT MSH2 MXD1 MXD3 MXD4 MXI1 MYC MYCL MYCLP1 MYCN PLEKHA5 PLEKHF2 PLIN3 RPL34 RPL35 SMAD3 SMAD4 SNIP1 SPAG9 TAF1 TEAD1 TRRAP TUBA1A TXLNG UNC45A USP1 ZBTB17	13 interacting genes: DIRAS2 HSP90AA1 HSP90AB1 KRTAP10-3 LMNA MARCHF10 MAX MEOX1 MEOX2 MID2 PIBF1 SMAD9 TEKT1
Entrez ID		4149	55898
HPRD ID		01113	18070
Ensembl ID		ENSG00000125952	ENSG00000140553
Uniprot IDs		G3V302 G3V563 G3V5L1 P61244 Q6V3B1 Q8TAX8	Q9H3U1
PDB IDs		1AN2 1HLO 1NKP 1NLW 1R05 5EYO 6G6J 6G6K 6G6L 8OTS 8OTT	2DBA
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Chromatin Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Binding Nucleoplasm DNA Binding Positive Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MiRNA Metabolic Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of MiRNA Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Light Stimulus Regulation Of MiRNA Metabolic Process Response To UV Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transforming Growth Factor Beta2 Production Response To Radiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Binding Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Neddylation Positive Regulation Of RNA Metabolic Process Intracellular Iron Ion Homeostasis Regulation Of Macromolecule Metabolic Process Striated Muscle Cell Differentiation Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process	Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Somite Specification Telomerase Holoenzyme Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Positive Regulation Of Macromolecule Biosynthetic Process Segment Specification Somite Development Chaperone-mediated Protein Complex Assembly Regulation Of Primary Metabolic Process Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Tau Protein Binding Protein Localization To Cytoskeleton CTP Binding DATP Binding Cellular Response To Heat Protein Folding Chaperone Regulation Of Metabolic Process Embryonic Pattern Specification Regulation Of Nitric Oxide Biosynthetic Process Protein Localization To Organelle Regulation Of Protein Modification Process Regulation Of Nitric Oxide Metabolic Process Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Myc-Max Complex Mad-Max Complex Negative Regulation Of Prostaglandin Biosynthetic Process DNA-binding Transcription Factor Activity
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