CEP250

Gene Name		centrosomal protein 250kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Centriole Microtubule Organizing Center Cytosol Cilium Spindle Pole Centrosome Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Protein Localization Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Height ( 18391951) Ulcerative colitis ( 23128233)
Protein-protein Interactions		6 interactors: APP ATF7IP KAT2B NEK2 PLEKHA5 YWHAG
Entrez ID		11190
HPRD ID		09877
Ensembl ID		ENSG00000126001
Uniprot IDs		Q9BV73
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Centriole-centriole Cohesion G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Synaptic Growth At Neuromuscular Junction Notch Signaling Pathway Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Collateral Sprouting In Absence Of Injury Regulation Of Centriole-centriole Cohesion N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Cellular Response To Insulin Stimulus Regulation Of Mitotic Centrosome Separation Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Chromosome Organization Cell Cycle Process Axon Choice Point Recognition Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Phosphorylation Regulation Of Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Response To Insulin Neuron Remodeling Negative Regulation Of Transferase Activity Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Glycosylation Negative Regulation Of Protein Phosphorylation Cellular Response To Peptide Regulation Of Phosphorylation N-terminal Protein Amino Acid Acetylation Positive Regulation Of Transcription, DNA-templated Cell Cycle Organelle Organization Centrosome Separation Negative Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process
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