CYP2D6 and CYB5A

Number of citations of the paper that reports this interaction (PMID 15680923)
10

Data Source:
BioGRID (pull down)

		CYP2D6	CYB5A
Gene Name		cytochrome P450, family 2, subfamily D, polypeptide 6	cytochrome b5 type A (microsomal)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Monooxygenase Activity Iron Ion Binding Drug Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity	Aldo-keto Reductase (NADP) Activity Cytochrome-c Oxidase Activity Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process	Xenobiotic Metabolic Process Steroid Metabolic Process Coumarin Metabolic Process Alkaloid Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Small Molecule Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Binding Oxidation-reduction Process Oxidative Demethylation Negative Regulation Of Cellular Organofluorine Metabolic Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process L-ascorbic Acid Metabolic Process Small Molecule Metabolic Process Response To Cadmium Ion Oxidation-reduction Process Hydrogen Ion Transmembrane Transport
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Miscellaneous substrates Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Fatty acids Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		Paliperidone	Heme Dimethyl Propionate Ester Heme
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CYB5A CYP2C9 POR	15 interactors: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 CYP4F2 POR SCD UGT1A4
Entrez ID		1565	1528
HPRD ID		00487	08941
Ensembl ID		ENSG00000100197	ENSG00000166347
Uniprot IDs		C1ID52 P10635 Q5Y7H2	P00167
PDB IDs		2F9Q 3QM4 3TBG 3TDA	2I96
Enriched GO Terms of Interacting Partners?		Demethylation Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cellular Organofluorine Metabolic Process Nitric Oxide Catabolic Process Nitrate Catabolic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Oxidation-reduction Process Nitrate Metabolic Process Fatty Acid Metabolic Process Monoterpenoid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Small Molecule Metabolic Process Omega-hydroxylase P450 Pathway Positive Regulation Of Hormone Biosynthetic Process Response To Drug L-ascorbic Acid Metabolic Process Oxidative Demethylation Urea Metabolic Process Monocarboxylic Acid Metabolic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Epoxygenase P450 Pathway Amino-acid Betaine Metabolic Process Negative Regulation Of Lipase Activity Regulation Of Cholesterol Biosynthetic Process Exogenous Drug Catabolic Process Response To Follicle-stimulating Hormone Drug Catabolic Process Cellular Response To Gonadotropin Stimulus Flavonoid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Nitric Oxide Metabolic Process Regulation Of Cholesterol Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Chondrocyte Differentiation Regulation Of Hormone Metabolic Process Drug Metabolic Process Cellular Lipid Metabolic Process Positive Regulation Of Oxidoreductase Activity Response To Gonadotropin Positive Regulation Of Cartilage Development Positive Regulation Of Smoothened Signaling Pathway Response To Cadmium Ion Positive Regulation Of Lipid Biosynthetic Process Arachidonic Acid Metabolic Process	Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Drug Metabolic Process Epoxygenase P450 Pathway Oxidation-reduction Process Exogenous Drug Catabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Drug Catabolic Process Arachidonic Acid Metabolic Process Carboxylic Acid Metabolic Process Fatty Acid Metabolic Process Icosanoid Metabolic Process Monocarboxylic Acid Metabolic Process Unsaturated Fatty Acid Metabolic Process Lipid Metabolic Process Long-chain Fatty Acid Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Response To Drug Omega-hydroxylase P450 Pathway Catabolic Process Cellular Lipid Metabolic Process Demethylation Coumarin Metabolic Process Isoprenoid Metabolic Process Dibenzo-p-dioxin Metabolic Process Alkaloid Metabolic Process Toxin Metabolic Process Oxidative Demethylation Flavonoid Metabolic Process Vitamin Metabolic Process Alkaloid Catabolic Process Pressure Natriuresis Leukotriene B4 Catabolic Process Cellular Metabolic Process Cellular Response To Stimulus Porphyrin-containing Compound Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Long-chain Fatty Acid Catabolic Process Response To Herbicide Heterocycle Metabolic Process Hydrogen Peroxide Biosynthetic Process Lipid Catabolic Process Cellular Ketone Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Tetrapyrrole Metabolic Process Lipid Biosynthetic Process Vitamin D Metabolic Process
Tagcloud ?		ab associations bcc bccs comprised cytochrome em genotypes glutathione gstm1 gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 serpinb9 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Difference) ?		ab associations bcc bccs comprised cytochrome em genotypes glutathione gstm1 gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 serpinb9 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Intersection) ?