CYP2D6 and CYP2C9

Number of citations of the paper that reports this interaction (PubMedID 19448135)
29

Data Source:
BioGRID (pull down)

		CYP2D6	CYP2C9
Description		cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)	cytochrome P450 family 2 subfamily C member 9
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Metal Ion Binding Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity	Monooxygenase Activity Iron Ion Binding Arachidonate Epoxygenase Activity Steroid Hydroxylase Activity Arachidonate 14,15-epoxygenase Activity Arachidonate 11,12-epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Heme Binding Caffeine Oxidase Activity Metal Ion Binding (R)-limonene 6-monooxygenase Activity Estrogen 2-hydroxylase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Coumarin Metabolic Process Alkaloid Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Arachidonate Metabolic Process Isoquinoline Alkaloid Metabolic Process Xenobiotic Catabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process Oxidative Demethylation Negative Regulation Of Organofluorine Metabolic Process	Lipid Metabolic Process Terpenoid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Monoterpenoid Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Long-chain Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Oxidative Demethylation Organofluorine Metabolic Process Omega-hydroxylase P450 Pathway
Pathways		Fatty acids Miscellaneous substrates Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs Aspirin ADME	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs Aspirin ADME
Drugs		Cannabidiol Diacerein Nabiximols	Ferroheme C Diacerein Benzbromarone
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Intelligence ( 28530673) Refractive error ( 32231278) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Schizophrenia ( 25056061 29483656) Urinary metabolite levels in chronic kidney disease ( 31959995)	Clopidogrel active metabolite levels ( 28207573) Dehydroepiandrosterone sulphate levels ( 21533175) Diastolic blood pressure ( 27841878) Glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Immune response to smallpox vaccine (IL-6) ( 22542470) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 19706858 28207573) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 27841878) Warfarin maintenance dose ( 26265036 18535201 23755828 20833655 19300499)
Interacting Genes		3 interacting genes: CYB5A CYP2C9 POR	10 interacting genes: CDC37 CYP2D6 CYP3A4 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A
Entrez ID		1565	1559
HPRD ID		00487	03084
Ensembl ID		ENSG00000100197	ENSG00000138109
Uniprot IDs		C1ID52 P10635 Q5Y7H2	P11712 S5RV20
PDB IDs		2F9Q 3QM4 3TBG 3TDA 4WNT 4WNU 4WNV 4WNW 4XRY 4XRZ 5TFT 5TFU 6CSB 6CSD	1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI 6VLT 7RL2 8VX0 8VZ7
Enriched GO Terms of Interacting Partners?		Organofluorine Metabolic Process Intracellular Membrane-bounded Organelle Demethylation Heme Binding Xenobiotic Metabolic Process Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Endoplasmic Reticulum Membrane (S)-limonene 7-monooxygenase Activity Arachidonate 11,12-epoxygenase Activity (R)-limonene 6-monooxygenase Activity (S)-limonene 6-monooxygenase Activity Arachidonate 14,15-epoxygenase Activity Nitric Oxide Catabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Endoplasmic Reticulum Caffeine Oxidase Activity Fatty Acid Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Monoterpenoid Metabolic Process Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Oxidative Demethylation Estrogen 2-hydroxylase Activity Enzyme Binding Positive Regulation Of Hormone Biosynthetic Process Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Flavonoid Metabolic Process Carnitine Metabolic Process Monocarboxylic Acid Metabolic Process Urea Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Nitrogen Cycle Metabolic Process Epoxygenase P450 Pathway FMN Binding Steroid Hydroxylase Activity Oxidoreductase Activity Regulation Of Hormone Levels Response To Follicle-stimulating Hormone Amino-acid Betaine Metabolic Process Regulation Of Steroid Hormone Biosynthetic Process Positive Regulation Of Chondrocyte Differentiation Cellular Response To Gonadotropin Stimulus Nitric Oxide Biosynthetic Process Regulation Of Hormone Biosynthetic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Xenobiotic Catabolic Process	Demethylation Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Alkaloid Catabolic Process Monoterpenoid Metabolic Process Oxidative Demethylation Alkaloid Metabolic Process Xenobiotic Metabolic Process Intracellular Membrane-bounded Organelle Xenobiotic Catabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Estrogen Metabolic Process Long-chain Fatty Acid Biosynthetic Process Retinol Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Fatty Acid Metabolic Process Organic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Negative Regulation Of Organofluorine Metabolic Process Secondary Metabolic Process Quinine 3-monooxygenase Activity 1,8-cineole 2-exo-monooxygenase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Monooxygenase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Retinoid Metabolic Process Diterpenoid Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Vitamin D 24-hydroxylase Activity Vitamin D3 25-hydroxylase Activity Nitric Oxide Catabolic Process Organofluorine Metabolic Process Positive Regulation Of Mast Cell Differentiation HSP90-CDC37 Chaperone Complex Terpenoid Metabolic Process Long-chain Fatty Acid Metabolic Process Isoprenoid Metabolic Process Regulation Of Biological Quality Coumarin Metabolic Process Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Regulation Of Steroid Metabolic Process
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