CYP2D6

Gene Name		cytochrome P450, family 2, subfamily D, polypeptide 6
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Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Drug Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity
	Biological Process	Xenobiotic Metabolic Process Steroid Metabolic Process Coumarin Metabolic Process Alkaloid Metabolic Process Alkaloid Catabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Arachidonic Acid Metabolic Process Isoquinoline Alkaloid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Small Molecule Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Binding Oxidation-reduction Process Oxidative Demethylation Negative Regulation Of Cellular Organofluorine Metabolic Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Miscellaneous substrates Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Fatty acids Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs		Paliperidone
Diseases
GWAS
Protein-protein Interactions		3 interactors: CYB5A CYP2C9 POR
Entrez ID		1565
HPRD ID		00487
Ensembl ID		ENSG00000100197
Uniprot IDs		C1ID52 P10635 Q5Y7H2
PDB IDs		2F9Q 3QM4 3TBG 3TDA
Enriched GO Terms of Interacting Partners?		Demethylation Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cellular Organofluorine Metabolic Process Nitric Oxide Catabolic Process Nitrate Catabolic Process Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Oxidation-reduction Process Nitrate Metabolic Process Fatty Acid Metabolic Process Monoterpenoid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Small Molecule Metabolic Process Omega-hydroxylase P450 Pathway Positive Regulation Of Hormone Biosynthetic Process Response To Drug L-ascorbic Acid Metabolic Process Oxidative Demethylation Urea Metabolic Process Monocarboxylic Acid Metabolic Process Carnitine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Epoxygenase P450 Pathway Amino-acid Betaine Metabolic Process Negative Regulation Of Lipase Activity Regulation Of Cholesterol Biosynthetic Process Exogenous Drug Catabolic Process Response To Follicle-stimulating Hormone Drug Catabolic Process Cellular Response To Gonadotropin Stimulus Flavonoid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Nitric Oxide Metabolic Process Regulation Of Cholesterol Metabolic Process Reactive Nitrogen Species Metabolic Process Positive Regulation Of Chondrocyte Differentiation Regulation Of Hormone Metabolic Process Drug Metabolic Process Cellular Lipid Metabolic Process Positive Regulation Of Oxidoreductase Activity Response To Gonadotropin Positive Regulation Of Cartilage Development Positive Regulation Of Smoothened Signaling Pathway Response To Cadmium Ion Positive Regulation Of Lipid Biosynthetic Process Arachidonic Acid Metabolic Process
Tagcloud ?		ab associations bcc bccs comprised cytochrome em genotypes glutathione gstm1 gstt1 heterogeneity lesion mpp null numbers p450 phenotype presentation presentations reflect reflects spp subgroup subgroups transferase truncal unidentified uv