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POLR2J and CD14
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
POLR2J
CD14
Gene Name
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
CD14 molecule
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
DNA-directed RNA Polymerase II, Core Complex
Extracellular Region
Extracellular Space
Plasma Membrane
Cell Surface
Endosome Membrane
Anchored Component Of Membrane
Membrane Raft
Extracellular Vesicular Exosome
Molecular Function
RNA Polymerase II Activity
DNA Binding
DNA-directed RNA Polymerase Activity
Protein Binding
LRR Domain Binding
Protein Dimerization Activity
Lipopolysaccharide Binding
Opsonin Receptor Activity
Protein Binding
Peptidoglycan Receptor Activity
Lipoteichoic Acid Binding
Biological Process
MRNA Splicing, Via Spliceosome
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
RNA Splicing
Gene Expression
Viral Process
PiRNA Metabolic Process
Somatic Stem Cell Maintenance
Positive Regulation Of Viral Transcription
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Phagocytosis
Apoptotic Process
Inflammatory Response
Cell Surface Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Response To Heat
Response To Magnesium Ion
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Tumor Necrosis Factor
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Innate Immune Response
Response To Ethanol
Positive Regulation Of Endocytosis
Positive Regulation Of Cytokine Secretion
Response To Electrical Stimulus
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Pathways
RNA Polymerase II Promoter Escape
mRNA Splicing
Formation of HIV-1 elongation complex containing HIV-1 Tat
PIWI-interacting RNA (piRNA) biogenesis
Nucleotide Excision Repair
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription
Abortive elongation of HIV-1 transcript in the absence of Tat
HIV Infection
Regulatory RNA pathways
Formation of the Early Elongation Complex
Tat-mediated elongation of the HIV-1 transcript
Tat-mediated HIV elongation arrest and recovery
Formation of transcription-coupled NER (TC-NER) repair complex
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II Pre-transcription Events
Dual incision reaction in TC-NER
Influenza Life Cycle
HIV elongation arrest and recovery
HIV Life Cycle
HIV Transcription Initiation
Influenza Viral RNA Transcription and Replication
RNA Pol II CTD phosphorylation and interaction with CE
Transcriptional regulation of pluripotent stem cells
RNA Polymerase II HIV Promoter Escape
HIV Transcription Elongation
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation by small RNAs
Processing of Capped Intron-Containing Pre-mRNA
mRNA Capping
mRNA Splicing - Minor Pathway
mRNA Splicing - Major Pathway
MicroRNA (miRNA) biogenesis
Influenza Infection
Pausing and recovery of Tat-mediated HIV elongation
Late Phase of HIV Life Cycle
Formation of RNA Pol II elongation complex
RNA Polymerase II Transcription Initiation And Promoter Clearance
Pausing and recovery of HIV elongation
Formation of HIV elongation complex in the absence of HIV Tat
Transcription-coupled NER (TC-NER)
Viral Messenger RNA Synthesis
Formation of the HIV-1 Early Elongation Complex
RNA Polymerase II Transcription Initiation
Transcription of the HIV genome
RNA Polymerase II Transcription Elongation
TRAF6 mediated induction of TAK1 complex
IKK complex recruitment mediated by RIP1
TRIF-mediated TLR3/TLR4 signaling
MyD88-independent cascade
Toll Like Receptor TLR6:TLR2 Cascade
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Transfer of LPS from LBP carrier to CD14
Toll Like Receptor 2 (TLR2) Cascade
Activated TLR4 signalling
Toll Like Receptor TLR1:TLR2 Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
MyD88:Mal cascade initiated on plasma membrane
TRIF-mediated programmed cell death
Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
8 interactors:
AATF
BAG6
CD14
LARP1B
POLR1C
POLR2C
POLR2K
SATB1
14 interactors:
ARFGAP3
CD55
GJB2
IRAK3
ITGB2
LBP
LGALS3BP
LTF
POLR2J
PPP3R2
TLR2
TLR3
TLR4
TNFRSF1B
Entrez ID
5439
929
HPRD ID
16038
01151
Ensembl ID
ENSG00000005075
ENSG00000170458
Uniprot IDs
P52435
P08571
PDB IDs
4GLP
Enriched GO Terms of Interacting Partners
?
DNA-templated Transcription, Elongation
Termination Of RNA Polymerase III Transcription
Transcription Elongation From RNA Polymerase III Promoter
Termination Of RNA Polymerase I Transcription
Transcription Elongation From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
DNA-templated Transcription, Initiation
7-methylguanosine MRNA Capping
Transcription From RNA Polymerase I Promoter
PiRNA Metabolic Process
7-methylguanosine RNA Capping
Cellular Response To DNA Damage Stimulus
Response To Stress
Transcription-coupled Nucleotide-excision Repair
Positive Regulation Of Viral Transcription
Transcription From RNA Polymerase III Promoter
Apoptotic Process
Programmed Cell Death
Immune System Process
Positive Regulation Of Cytokine Production
Cell Death
Death
Transcription Elongation From RNA Polymerase II Promoter
Somatic Stem Cell Maintenance
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
DNA-templated Transcription, Termination
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Type I Interferon Production
Nucleotide-excision Repair
Regulation Of Cytokine Production
Viral Process
Regulation Of Type I Interferon Production
Regulation Of Gene Expression
Cellular Response To Stress
Response To Stimulus
Stem Cell Maintenance
Regulation Of Viral Process
Transcription Initiation From RNA Polymerase II Promoter
Innate Immune Response
Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process
Negative Regulation Of Superoxide Anion Generation
Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression, Epigenetic
Tail-anchored Membrane Protein Insertion Into ER Membrane
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Stem Cell Development
Transcription, DNA-templated
Protein Insertion Into ER Membrane
Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Response To Other Organism
Response To Biotic Stimulus
Macrophage Activation
Positive Regulation Of Interleukin-8 Production
Regulation Of Interleukin-6 Production
Regulation Of Innate Immune Response
Response To Bacterium
Defense Response
Regulation Of Inflammatory Response
Positive Regulation Of Immune System Process
Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
Positive Regulation Of Chemokine Production
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Immune Response
Regulation Of Chemokine Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Stress
Defense Response To Bacterium
Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Cytokine Biosynthetic Process
Inflammatory Response
Detection Of Molecule Of Bacterial Origin
Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
Cellular Response To Lipoteichoic Acid
Response To External Stimulus
I-kappaB Phosphorylation
Negative Regulation Of Cytokine Production
Innate Immune Response
Immune Response
Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Regulation Of Tumor Necrosis Factor Biosynthetic Process
Positive Regulation Of Inflammatory Response
Regulation Of Cytokine Production
Positive Regulation Of NF-kappaB Import Into Nucleus
Immune System Process
Regulation Of Protein Metabolic Process
Tagcloud
?
1beta
1ra
antiinflammatory
bmmc
ccf
cd11b
cd16
cd64
cd68
cd95
cholecalciferol
explain
granulocyte
immature
immunoassay
methotrexate
monoblastic
monocytic
mononuclear
mtx
oh
p75
pbmc
rheumatoid
sorter
stnfr
supernatants
u937
undifferentiated
Tagcloud (Difference)
?
1beta
1ra
antiinflammatory
bmmc
ccf
cd11b
cd16
cd64
cd68
cd95
cholecalciferol
explain
granulocyte
immature
immunoassay
methotrexate
monoblastic
monocytic
mononuclear
mtx
oh
p75
pbmc
rheumatoid
sorter
stnfr
supernatants
u937
undifferentiated
Tagcloud (Intersection)
?