POLR2J and DRC12

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		POLR2J	DRC12
Name		RNA polymerase II subunit J	dynein regulatory complex subunit 12 homolog
Structure			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex	Cytoplasm Cytoskeleton Cilium Motile Cilium Cell Projection
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding LRR Domain Binding Protein Dimerization Activity	Protein Binding Identical Protein Binding
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase II	None
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	None
GWAS		Chronotype ( 30696823 )	No GWAS studies recorded
Interacting Genes		15 interacting genes: AATF BAG6 CD14 DRC12 LARP1B MYOG NTAQ1 OIP5 POLR2C SATB1 SDCBP SNAPC5 TENM1 TRAF4 VPS37C	18 interacting genes: AIMP2 BFSP2 C19orf25 CDR2 CDR2L DDIT3 DTNBP1 FAM124B GNMT GORASP2 GUCD1 NECAB2 NUP62 PIN1 POLR2J PSMA1 SPG21 STX5
Entrez ID		5439	283152
HPRD ID		16038	18762
Ensembl ID		ENSG00000005075	ENSG00000248712
Uniprot IDs		P52435	Q494R4
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4	Not available
GO Terms Enriched among Interactors		Protein Targeting To Membrane	None