POLR2J and SATB1

Number of citations: 0 (PubMedID 12036295)
Data Source: BioGRID (two hybrid, pull down), HPRD (two hybrid, in vitro)

		POLR2J	SATB1
Name		RNA polymerase II subunit J	SATB homeobox 1
Structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex	Chromatin Nucleus Nucleoplasm Nuclear Matrix Nuclear Body PML Body Nuclear Lumen
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding LRR Domain Binding Protein Dimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins
GWAS		Chronotype ( 30696823 )	Adventurousness ( 30643258 ) Aspartate aminotransferase levels ( 33547301 ) Chronic mucus hypersecretion ( 24714607 ) Familial lung adenocarcinoma ( 29924316 ) General risk tolerance (MTAG) ( 30643258 ) Itch intensity from mosquito bite ( 28199695 ) Left-handedness ( 32989287 ) Parkinson's disease ( 28892059 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Platelet count ( 22139419 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Sjögren's syndrome ( 24097067 )
Interacting Genes		15 interacting genes: AATF BAG6 CD14 DRC12 LARP1B MYOG NTAQ1 OIP5 POLR2C SATB1 SDCBP SNAPC5 TENM1 TRAF4 VPS37C	28 interacting genes: BAZ1A CASP6 CBS CBX4 CHD3 CUX1 EP300 FOXP1 FOXP2 FOXP4 GATA3 HDAC1 KAT2B MEOX2 MTA2 PIAS1 PIAS3 PIAS4 POLR2J SIRT1 SMARCA5 SPG21 SUMO1 SUMO1P1 TOPORS UBE2I UBR5 USP16
Entrez ID		5439	6304
HPRD ID		16038	03647
Ensembl ID		ENSG00000005075	ENSG00000182568
Uniprot IDs		P52435	Q01826
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4	1YSE 2L1P 2MW8 2O49 2O4A 3NZL 3TUO 6LFF
GO Terms Enriched among Interactors		Protein Targeting To Membrane	Negative Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of DNA-templated Transcription Chromatin Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II PML Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Chromatin Organization Post-translational Protein Modification Chromatin Remodeling SUMO Ligase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Transcription Coregulator Activity Protein Modification By Small Protein Conjugation Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Androgen Receptor Signaling Pathway DNA Damage Response DNA-binding Transcription Factor Binding Cellular Response To Stress Zinc Ion Binding Positive Regulation Of Metabolic Process Regulation Of Cell Fate Commitment Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Corepressor Activity Peptidyl-lysine Acetylation Positive Regulation Of Protein Sumoylation Metal Ion Binding NuRD Complex