POLR2E and POLR2C

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vitro)

		POLR2E	POLR2C
Description		RNA polymerase II, I and III subunit E	RNA polymerase II subunit C
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol RPAP3/R2TP/prefoldin-like Complex	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Cytosol
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	DNA-templated Transcription Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II TRNA Transcription By RNA Polymerase III Protein Stabilization	DNA-templated Transcription Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Cortical amyloid beta load ( 29860282) Menopause (age at onset) ( 26414677)
Interacting Genes		29 interacting genes: CHGB FKBP14 FOS GTF2F2 HSP90B1 IKBKG IP6K3 ITCH LZTR1 NEDD4 PML POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2K POLR2L SRPK1 SYT5 TAF15 TRIM29 TRIM55 TRIM63 UBE2D1 UBE2D4 URI1 ZSCAN1	32 interacting genes: ATF4 ATF7IP C11orf58 CCHCR1 EEF1A1 ERG28 ITCH LRIF1 MYOG NECAB2 NEDD4 NFKBIA NUDT21 OTUD5 POLR2A POLR2B POLR2D POLR2E POLR2F POLR2G POLR2H POLR2J POLR2J2 POLR2K POLR2L RPAP1 RSPH1 SMARCC2 STC2 TAF15 UBC UBE2W
Entrez ID		5434	5432
HPRD ID		15946	15945
Ensembl ID		ENSG00000099817	ENSG00000102978
Uniprot IDs		B4DJ89 E5KT65 P19388	P19387 Q6FGR6
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7LBM 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9EHZ 9EI1 9EI3 9EI4 9FSO 9FSP 9FSQ 9FSR 9FSS	5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex Transcription By RNA Polymerase II DNA-templated Transcription DNA-directed RNA Polymerase Activity RNA Polymerase I Complex RNA Polymerase III Complex Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nucleus Protein K63-linked Ubiquitination Nucleoplasm Innate Immune Response Transcription By RNA Polymerase III Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Nucleic Acid Metabolic Process Protein K48-linked Ubiquitination Regulation Of RNA Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Transcription Initiation At RNA Polymerase II Promoter Response To External Biotic Stimulus Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification Protein Polyubiquitination Response To Other Organism TRNA Transcription By RNA Polymerase III TRNA Transcription Protein K29-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding DNA-templated Transcription Initiation Transcription By RNA Polymerase I Regulation Of Primary Metabolic Process Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Activity Protein Modification Process Defense Response Translation Initiation Factor Binding Regulation Of Gene Expression SMAD Protein Signal Transduction Transferase Activity Regulation Of Macromolecule Biosynthetic Process Medium-term Memory Cellular Response To Prolactin	RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex DNA-directed RNA Polymerase Activity Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase I Complex RNA Polymerase III Complex Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process Nucleus RNA Metabolic Process Nucleoplasm Nucleic Acid Metabolic Process Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III TRNA Transcription Nucleobase-containing Compound Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription Macromolecule Metabolic Process DNA Binding Regulation Of Transcription By RNA Polymerase I 5'-3' RNA Polymerase Activity Protein Monoubiquitination Nucleolus Transcription By RNA Polymerase I Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotidyltransferase Activity Translation Initiation Factor Binding Negative Regulation Of Gene Expression Negative Regulation Of Potassium Ion Transport
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