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POLR2E and PML
Number of citations of the paper that reports this interaction (PubMedID
20211142
)
41
Data Source:
BioGRID
(two hybrid)
POLR2E
PML
Description
RNA polymerase II, I and III subunit E
PML nuclear body scaffold
Image
GO Annotations
Cellular Component
DNA-directed RNA Polymerase Complex
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
RNA Polymerase III Complex
Nucleolus
RNA Polymerase I Complex
Cytosol
RPAP3/R2TP/prefoldin-like Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Nuclear Matrix
PML Body
Early Endosome Membrane
Nuclear Membrane
Molecular Function
DNA Binding
DNA-directed RNA Polymerase Activity
Protein Binding
DNA Binding
Transcription Coactivator Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
SUMO Binding
Identical Protein Binding
Protein Homodimerization Activity
SMAD Binding
Metal Ion Binding
Protein Heterodimerization Activity
Cobalt Ion Binding
Molecular Adaptor Activity
Ubiquitin-like Protein Ligase Activity
Biological Process
DNA-templated Transcription
Transcription Elongation By RNA Polymerase I
Transcription By RNA Polymerase II
TRNA Transcription By RNA Polymerase III
Protein Stabilization
Response To Hypoxia
Positive Regulation Of Defense Response To Virus By Host
Immune System Process
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Protein Targeting
Protein Import Into Nucleus
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Response To UV
Response To Gamma Radiation
Regulation Of Calcium Ion Transport Into Cytosol
Negative Regulation Of Gene Expression
Fibroblast Migration
Negative Regulation Of Angiogenesis
Protein Sumoylation
Myeloid Cell Differentiation
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
PML Body Organization
Protein-containing Complex Localization
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-1 Production
Circadian Regulation Of Gene Expression
Negative Regulation Of Translation In Response To Oxidative Stress
Response To Cytokine
Protein Localization To Nucleus
Regulation Of Circadian Rhythm
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Entrainment Of Circadian Clock By Photoperiod
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Suppression Of Viral Release By Host
Innate Immune Response
Cell Fate Commitment
Establishment Of Protein Localization
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Fibroblast Proliferation
Retinoic Acid Receptor Signaling Pathway
Rhythmic Process
Protein Stabilization
Regulation Of Protein Metabolic Process
Maintenance Of Protein Location In Nucleus
Defense Response To Virus
Regulation Of Cell Cycle
Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Regulation Of Cellular Localization
SMAD Protein Signal Transduction
Branching Involved In Mammary Gland Duct Morphogenesis
Protein-containing Complex Assembly
Regulation Of Biological Quality
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Interleukin-4
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Cellular Senescence
Oncogene-induced Cell Senescence
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Localization To Chromosome, Telomeric Region
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Double-strand Break Repair
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
Cytosolic sensors of pathogen-associated DNA
MicroRNA (miRNA) biogenesis
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase III Chain Elongation
RNA Polymerase I Transcription Termination
RNA Polymerase III Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Regulation of TP53 Activity through Acetylation
Interferon gamma signaling
Regulation of RUNX1 Expression and Activity
Regulation of PTEN localization
HCMV Early Events
Drugs
Arsenic trioxide
Diseases
Acute myeloid leukemia (AML)
GWAS
Cortical amyloid beta load (
29860282
)
Menopause (age at onset) (
26414677
)
Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) (
29899525
)
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Height (
20881960
25282103
28552196
)
Hip circumference adjusted for BMI (
34021172
)
Insomnia symptoms (never/rarely vs. sometimes/usually) (
30804566
)
Insomnia symptoms (never/rarely vs. usually) (
30804566
)
Myopia (pathological) (
23049088
)
Paget's disease (
21623375
)
Physical activity (overall physical activity time) (
30531941
)
White blood cell count (
32888494
)
Interacting Genes
29 interacting genes:
CHGB
FKBP14
FOS
GTF2F2
HSP90B1
IKBKG
IP6K3
ITCH
LZTR1
NEDD4
PML
POLR2A
POLR2C
POLR2D
POLR2F
POLR2G
POLR2H
POLR2K
POLR2L
SRPK1
SYT5
TAF15
TRIM29
TRIM55
TRIM63
UBE2D1
UBE2D4
URI1
ZSCAN1
111 interacting genes:
ADH1B
ANKRD2
ARID3A
ARNT
ATF2
ATXN1
AURKA
AXIN1
BANP
BCL2
BCL6
CASP8AP2
CCNT1
CDK1
CDK2
CDK6
CHEK2
CHFR
CREBBP
CSNK2A1
DAXX
EGFR
EIF4E
ELF4
EP300
ERCC6
FOS
FXR1
GATA1
GATA2
HDAC1
HDAC2
HDAC3
HHEX
HIPK2
HTT
KAT5
KAT6A
KLHL20
MAD1L1
MAPK11
MAPK14
MDM2
MED7
MXD1
MYB
MYC
NACC1
NCOA2
NCOR1
NCOR2
NFKB1
NR4A1
PAWR
PAXIP1
PCBD2
PIAS1
PIAS2
PIN1
PLAGL1
PLSCR1
POLR2E
PSMA3
RARA
RB1
RBX1
RELA
RNF125
RPL11
RXRA
SENP1
SENP2
SH3GL1
SIAH2
SIN3A
SIRT1
SKI
SMAD3
SNCA
SP1
SP100
SRF
STAT3
SUMO1
SUMO2
SUMO3
SUV39H1
SYNE2
TDG
TERF2IP
TGFBR1
TGFBR2
TGIF1
THRA
TOPBP1
TP53
TP63
TP73
TRIB3
TRIM24
TRIM27
TRIM69
UBC
UBE2I
UBE2U
UBE3A
USP11
USP2
ZBTB16
ZFYVE9
ZNF451
Entrez ID
5434
5371
HPRD ID
15946
00023
Ensembl ID
ENSG00000099817
ENSG00000140464
Uniprot IDs
B4DJ89
E5KT65
P19388
P29590
PDB IDs
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
6XRE
7A6H
7AE1
7AE3
7AEA
7AST
7D58
7D59
7DN3
7DU2
7FJI
7FJJ
7LBM
7OB9
7OBA
7OBB
7VBA
7VBB
7VBC
8A43
8ITY
8IUE
8IUH
9EHZ
9EI1
9EI3
9EI4
9FSO
9FSP
9FSQ
9FSR
9FSS
1BOR
2MVW
2MWX
4WJN
4WJO
5YUF
6IMQ
6UYO
6UYP
6UYQ
6UYR
6UYS
6UYT
6UYU
6UYV
8DJH
8DJI
8J25
8J2P
8YTC
Enriched GO Terms of Interacting Partners
?
RNA Polymerase II, Core Complex
DNA-directed RNA Polymerase Complex
Transcription By RNA Polymerase II
DNA-templated Transcription
DNA-directed RNA Polymerase Activity
RNA Polymerase I Complex
RNA Polymerase III Complex
Nucleobase-containing Compound Biosynthetic Process
RNA Metabolic Process
Macromolecule Metabolic Process
Macromolecule Biosynthetic Process
Nucleus
Protein K63-linked Ubiquitination
Nucleoplasm
Innate Immune Response
Transcription By RNA Polymerase III
Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Modification By Small Protein Conjugation
Nucleic Acid Metabolic Process
Protein K48-linked Ubiquitination
Regulation Of RNA Metabolic Process
Defense Response To Symbiont
Defense Response To Other Organism
Transcription Initiation At RNA Polymerase II Promoter
Response To External Biotic Stimulus
Ubiquitin-protein Transferase Activity
Protein Ubiquitination
Post-translational Protein Modification
Protein Polyubiquitination
Response To Other Organism
TRNA Transcription By RNA Polymerase III
TRNA Transcription
Protein K29-linked Ubiquitination
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
DNA Binding
DNA-templated Transcription Initiation
Transcription By RNA Polymerase I
Regulation Of Primary Metabolic Process
Nucleobase-containing Compound Metabolic Process
Ubiquitin Protein Ligase Activity
Protein Modification Process
Defense Response
Translation Initiation Factor Binding
Regulation Of Gene Expression
SMAD Protein Signal Transduction
Transferase Activity
Regulation Of Macromolecule Biosynthetic Process
Medium-term Memory
Cellular Response To Prolactin
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nucleoplasm
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Nucleus
PML Body
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Chromatin Binding
DNA-binding Transcription Factor Binding
DNA-templated Transcription
Apoptotic Process
Transcription By RNA Polymerase II
Macromolecule Metabolic Process
Regulation Of Signal Transduction
Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Cell Communication
Programmed Cell Death
Cell Death
Regulation Of Cell Cycle
Transcription Regulator Complex
Intracellular Signal Transduction
Chromatin
Regulation Of Multicellular Organismal Process
Regulation Of Cell Differentiation
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Tagcloud (Intersection)
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