POLR2E and TAF15

Number of citations of the paper that reports this interaction (PMID 9488465)
43

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		POLR2E	TAF15
Gene Name		polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex DNA-directed RNA Polymerase III Complex DNA-directed RNA Polymerase I Complex Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase I Activity RNA Polymerase II Activity RNA Polymerase III Activity DNA Binding DNA-directed RNA Polymerase Activity Protein Binding	Nucleotide Binding DNA Binding Protein Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription RNA Splicing Gene Expression Viral Process Positive Regulation Of Type I Interferon Production PiRNA Metabolic Process Somatic Stem Cell Maintenance Regulation Of Gene Expression, Epigenetic Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription	Positive Regulation Of Transcription, DNA-templated
Pathways		RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation Abortive elongation of HIV-1 transcript in the absence of Tat RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Regulatory RNA pathways Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER Influenza Life Cycle RNA Polymerase III Transcription Termination HIV elongation arrest and recovery NoRC negatively regulates rRNA expression Influenza Viral RNA Transcription and Replication RNA Polymerase III Chain Elongation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 1 Promoter mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle RNA Polymerase III Transcription Initiation From Type 2 Promoter Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Abortive And Retractive Initiation Transcription of the HIV genome Nucleotide Excision Repair PIWI-interacting RNA (piRNA) biogenesis mRNA Splicing RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Innate Immune System RNA Polymerase III Transcription Initiation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Cytosolic sensors of pathogen-associated DNA Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Pausing and recovery of HIV elongation Formation of the HIV-1 Early Elongation Complex Viral Messenger RNA Synthesis RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: CHGB FKBP14 FOS GTF2B GTF2F2 HSP90B1 IKBKG ITCH LZTR1 NEDD4 PML POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2K POLR2L SRPK1 SYT5 TAF15 TRIM29 URI1 ZSCAN1	21 interactors: CACNA1A FUS HIST1H3A HIST2H2AC HIST2H4A HIST3H3 POLR2C POLR2E POLR2G PRMT1 PRMT8 SAFB SF1 TAF1 TAF12 TAF13 TAF5 TAF7 TBP YWHAG ZNF384
Entrez ID		5434	8148
HPRD ID		15946	09031
Ensembl ID			ENSG00000172660
Uniprot IDs		B4DJ89 P19388	Q86X94 Q92804
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Viral Process 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Positive Regulation Of Viral Process Positive Regulation Of Viral Transcription Regulation Of Viral Process PiRNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Viral Transcription Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Nitrogen Compound Metabolic Process Nucleotide-excision Repair RNA Splicing Regulation Of RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Transcription, DNA-templated Stem Cell Maintenance RNA Biosynthetic Process Regulation Of Gene Expression MRNA Processing Regulation Of RNA Biosynthetic Process RNA Metabolic Process Cellular Response To Stress Gene Expression MRNA Metabolic Process Regulation Of Metabolic Process RNA Processing Stem Cell Development Stem Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Type I Interferon Production Cellular Macromolecule Biosynthetic Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Positive Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Innate Immune Response Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Response To Stress Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process	Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation DNA-templated Transcription, Elongation Transcription From RNA Polymerase II Promoter Gene Expression Viral Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Chromosome Organization Chromatin Organization Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Chromatin Silencing At RDNA Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Histone Modification MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression 7-methylguanosine MRNA Capping PiRNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Chromatin Silencing 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Negative Regulation Of Megakaryocyte Differentiation Cellular Metabolic Process Positive Regulation Of Viral Transcription Regulation Of Transcription, DNA-templated Chromatin Modification Cellular Macromolecule Biosynthetic Process RNA Splicing Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine MRNA Processing Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Somatic Stem Cell Maintenance Regulation Of Gene Expression, Epigenetic
Tagcloud ?		actinomycin amanitin binds crm1 cytoplasmic demonstrating elusive entire export exported exportin fact interactor interactors leptomycin modification pdrg1 prefoldin proteomic r2tp repressor rpb5 shuttling spectrometry stabilized stall unconventional uri	amyotrophic autosomal carriers coding conserved equivocal et ewsr1 exons export familial frontotemporal fus genotyped genotyping hnrnpa1 hnrnpa2b1 lobar nes neurodegeneration pathogenicity r471c relatives sequenced subject substitution tardbp tdp43 tremor
Tagcloud (Difference) ?		actinomycin amanitin binds crm1 cytoplasmic demonstrating elusive entire exported exportin fact interactor interactors leptomycin modification pdrg1 prefoldin proteomic r2tp repressor rpb5 shuttling spectrometry stabilized stall unconventional uri	amyotrophic autosomal carriers coding conserved equivocal et ewsr1 exons familial frontotemporal fus genotyped genotyping hnrnpa1 hnrnpa2b1 lobar nes neurodegeneration pathogenicity r471c relatives sequenced subject substitution tardbp tdp43 tremor
Tagcloud (Intersection) ?		export