POLR2E and TRIM29

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		POLR2E	TRIM29
Description		RNA polymerase II, I and III subunit E	tripartite motif containing 29
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol RPAP3/R2TP/prefoldin-like Complex	Cytoplasm Lysosome Adherens Junction
	Molecular Function	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding	P53 Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	DNA-templated Transcription Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase II TRNA Transcription By RNA Polymerase III Protein Stabilization	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Innate Immune Response Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Interferon gamma signaling
Drugs
Diseases
GWAS		Cortical amyloid beta load ( 29860282) Menopause (age at onset) ( 26414677)	Corneal curvature ( 22969067) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Resistance to antihypertensive treatment in hypertension ( 31545351) Retinal detachment or retinal break ( 31816047) Stroke (pediatric) ( 22990015)
Interacting Genes		29 interacting genes: CHGB FKBP14 FOS GTF2F2 HSP90B1 IKBKG IP6K3 ITCH LZTR1 NEDD4 PML POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2K POLR2L SRPK1 SYT5 TAF15 TRIM29 TRIM55 TRIM63 UBE2D1 UBE2D4 URI1 ZSCAN1	55 interacting genes: ACTN3 ANKS1A ATM CARD9 CCDC57 CDC34 CEP70 CRACR2A DISC1 DMRT1 FBF1 FBXL19 FXR2 GATA1 GCC1 GOLGA2 GTF2E1 H4C1 HCLS1 HDAC9 HINT1 IKBKG JAKMIP2 KAT5 KRT35 LZTS2 MAD1L1 MAPKAPK2 MED7 MID2 MLH1 MSH2 MTUS2 MYO15B NFKBID POLR2D POLR2E PRICKLE3 PRKCA RNF13 RNF8 SHOX2 SMAD9 SNAPC1 SP100 TAX1BP3 TRIM11 TRIM23 TRIM27 TRIP6 TSGA10 UBE2C UBE2E1 UBE2I VIM
Entrez ID		5434	23650
HPRD ID		15946	10280
Ensembl ID		ENSG00000099817	ENSG00000137699
Uniprot IDs		B4DJ89 E5KT65 P19388	B7Z5V5 B7Z8U9 E9PRL4 Q14134
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7LBM 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9EHZ 9EI1 9EI3 9EI4 9FSO 9FSP 9FSQ 9FSR 9FSS	2CSV
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex Transcription By RNA Polymerase II DNA-templated Transcription DNA-directed RNA Polymerase Activity RNA Polymerase I Complex RNA Polymerase III Complex Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nucleus Protein K63-linked Ubiquitination Nucleoplasm Innate Immune Response Transcription By RNA Polymerase III Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Nucleic Acid Metabolic Process Protein K48-linked Ubiquitination Regulation Of RNA Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Transcription Initiation At RNA Polymerase II Promoter Response To External Biotic Stimulus Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification Protein Polyubiquitination Response To Other Organism TRNA Transcription By RNA Polymerase III TRNA Transcription Protein K29-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding DNA-templated Transcription Initiation Transcription By RNA Polymerase I Regulation Of Primary Metabolic Process Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Activity Protein Modification Process Defense Response Translation Initiation Factor Binding Regulation Of Gene Expression SMAD Protein Signal Transduction Transferase Activity Regulation Of Macromolecule Biosynthetic Process Medium-term Memory Cellular Response To Prolactin	Negative Regulation Of Viral Transcription Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Nucleus Cytoskeleton Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Viral Transcription Regulation Of Skeletal Muscle Fiber Development Protein Ubiquitination Positive Regulation Of DNA Recombination Cytosol Positive Regulation Of Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Development Somatic Cell DNA Recombination Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA Recombination Signal Transduction By P53 Class Mediator Suppression Of Viral Release By Host Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Ligase Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Intracellular Signal Transduction Double-strand Break Repair Via Nonhomologous End Joining Nucleoplasm Protein Modification Process Guanine/thymine Mispair Binding Positive Regulation Of Biosynthetic Process Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Catabolic Process Protein Localization To Site Of Double-strand Break Positive Regulation Of Cell Development Regulation Of DNA Recombination Somatic Diversification Of Immunoglobulins Involved In Immune Response Regulation Of RNA Metabolic Process Negative Regulation Of Viral Process Macromolecule Catabolic Process Identical Protein Binding Protein Binding Signal Transduction In Response To DNA Damage Transcription Regulator Complex Positive Regulation Of Isotype Switching To IgA Isotypes
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