CACNA1H and KCNMA1

Number of citations of the paper that reports this interaction (PMID 14631046)
44

Data Source:
HPRD (in vivo)

		CACNA1H	KCNMA1
Gene Name		calcium channel, voltage-dependent, T type, alpha 1H subunit	potassium channel, calcium activated large conductance subfamily M alpha, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Caveola Integral Component Of Membrane Sarcolemma	Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Integral Component Of Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Low Voltage-gated Calcium Channel Activity Metal Ion Binding Scaffold Protein Binding	Actin Binding Voltage-gated Potassium Channel Activity Protein Binding Calcium-activated Potassium Channel Activity Metal Ion Binding Large Conductance Calcium-activated Potassium Channel Activity
	Biological Process	Transport Muscle Contraction Axon Guidance Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Biosynthetic Process Regulation Of Ion Transmembrane Transport Cellular Response To Potassium Ion Regulation Of Membrane Potential Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Positive Regulation Of Acrosome Reaction	Response To Hypoxia Potassium Ion Transport Response To Osmotic Stress Synaptic Transmission Blood Coagulation Cellular Potassium Ion Homeostasis Response To Carbon Monoxide Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Response To Calcium Ion Micturition Smooth Muscle Contraction Involved In Micturition Potassium Ion Transmembrane Transport
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth	Ca2+ activated K+ channels Platelet homeostasis Potassium Channels Nitric oxide stimulates guanylate cyclase cGMP effects
Drugs		Isradipine Cinnarizine Zonisamide Felodipine Nitrendipine Nifedipine Amiodarone Bepridil Mibefradil Flunarizine	Enflurane Chlorzoxazone Bendroflumethiazide Hydroflumethiazide Hydrochlorothiazide Cromoglicic acid Miconazole Diazoxide Halothane
Diseases
GWAS			Bone mineral density ( 22504420) Mortality among heart failure patients ( 20400778) Obesity ( 21708048)
Protein-Protein Interactions		2 interactors: GNG2 KCNMA1	6 interactors: CACNA1H GGT1 HMOX2 KCNMB1 MAP1A PTK2
Entrez ID		8912	3778
HPRD ID		07442	15967
Ensembl ID		ENSG00000196557	ENSG00000156113
Uniprot IDs		B3KQH9 O95180	B7ZMF5 D5MRH1 Q12791 Q59FH2 Q5SVJ8 Q6AI34 S4R453
PDB IDs			2K44 3MT5 3NAF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Volume Smooth Muscle Contraction Involved In Micturition Response To Carbon Monoxide Blood Coagulation Hemostasis Micturition Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Cellular Potassium Ion Homeostasis Urinary Bladder Smooth Muscle Contraction Response To Wounding Cellular Response To Prostaglandin E Stimulus Potassium Ion Homeostasis Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Cellular Response To Catecholamine Stimulus Cell Volume Homeostasis Dopamine Receptor Signaling Pathway Cellular Response To Glucagon Stimulus Cellular Response To Fatty Acid Excretion Response To Glucagon Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Smooth Muscle Contraction Response To Fatty Acid Response To Osmotic Stress Renal System Process Response To Calcium Ion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Acid Chemical Potassium Ion Transmembrane Transport Platelet Activation Potassium Ion Transport Muscle Contraction Response To Stress Muscle System Process	Glutathione Catabolic Process Aldosterone Biosynthetic Process Cortisol Biosynthetic Process Heme Oxidation Netrin-activated Signaling Pathway Cysteine Biosynthetic Process Positive Regulation Of Acrosome Reaction Mineralocorticoid Biosynthetic Process Negative Regulation Of Synapse Assembly Cellular Response To Potassium Ion Signal Complex Assembly Heme Catabolic Process Cysteine Metabolic Process Response To Potassium Ion Glucocorticoid Biosynthetic Process Regulation Of Acrosome Reaction Response To Metal Ion Detection Of Calcium Ion
Tagcloud ?		altering arborization biophysical blocker burst c456s cav3 changing channels dendrites dendritic determinants electrical epilepsy ethosuximide excitability firing generalized goals idiopathic indirectly influences oscillations p2 rebound seizure substantially transactivator tta	10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Difference) ?		altering arborization biophysical blocker burst c456s cav3 changing channels dendrites dendritic determinants electrical epilepsy ethosuximide excitability firing generalized goals idiopathic indirectly influences oscillations p2 rebound seizure substantially transactivator tta	10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Intersection) ?