CACNA1H and KCNMA1

Number of citations of the paper that reports this interaction (PubMedID 14631046)
0

Data Source:
HPRD (in vivo)

		CACNA1H	KCNMA1
Description		calcium voltage-gated channel subunit alpha1 H	potassium calcium-activated channel subfamily M alpha 1
Image
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex	Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Membrane Apical Plasma Membrane Monoatomic Ion Channel Complex Postsynaptic Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Low Voltage-gated Calcium Channel Activity Metal Ion Binding Scaffold Protein Binding	Actin Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Calcium-activated Potassium Channel Activity Identical Protein Binding Metal Ion Binding Large Conductance Calcium-activated Potassium Channel Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Monoatomic Ion Transmembrane Transport Cortisol Biosynthetic Process Cellular Response To Potassium Ion Regulation Of Membrane Potential Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Acrosome Reaction	Response To Hypoxia Monoatomic Ion Transport Potassium Ion Transport Response To Osmotic Stress Intracellular Potassium Ion Homeostasis Monoatomic Ion Transmembrane Transport Response To Carbon Monoxide Vasodilation Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Response To Calcium Ion Transmembrane Transport Micturition Smooth Muscle Contraction Involved In Micturition Potassium Ion Transmembrane Transport
Pathways		NCAM1 interactions Smooth Muscle Contraction Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Ca2+ activated K+ channels cGMP effects Sensory processing of sound by inner hair cells of the cochlea Acetylcholine inhibits contraction of outer hair cells
Drugs		Ergocalciferol Enflurane Isradipine Spironolactone Cinnarizine Nicardipine Nicardipine Verapamil Verapamil Zonisamide Felodipine Nitrendipine Nifedipine Bepridil Mibefradil Flunarizine Nilvadipine Nilvadipine Cannabidiol Trimebutine Barnidipine Aranidipine Benidipine Efonidipine Efonidipine Efonidipine Manidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols	Chlorzoxazone Bendroflumethiazide Procaine Hydroflumethiazide Ritodrine Hydrochlorothiazide Nitrendipine Miconazole Diazoxide Halothane Colforsin Dequalinium Trimebutine
Diseases
GWAS		Eosinophil count ( 32888494) Leukocyte telomere length ( 32109421) Mastocytosis (KIT D816V positive) ( 33421400)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Bell's palsy ( 33602968) Blood pressure ( 24954895) Bone mineral density (spine) ( 26911590) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31015462 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucocorticoid-induced osteonecrosis ( 26265699) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 28869591 30598549) Hypospadias ( 25108383) Initial pursuit acceleration ( 29064472) Intraocular pressure ( 31959993) Lean body mass ( 28552196) Lumbar spine bone mineral density ( 29499414 22504420) Male-pattern baldness ( 28196072) Mortality in heart failure ( 20400778) Myopia ( 27182965) Obesity ( 21708048) Refractive error ( 32231278) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556) Schizophrenia ( 33169155) Smoking cessation in chronic obstructive pulmonary disease ( 29631575) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		3 interacting genes: CCR4 GNG2 KCNMA1	6 interacting genes: CACNA1H GGT1 HMOX2 KCNMB1 MAP1A PTK2
Entrez ID		8912	3778
HPRD ID		07442	15967
Ensembl ID		ENSG00000196557	ENSG00000156113
Uniprot IDs		A0A1W2PQW2 A0AAA9YHH8 B3KQH9 H3BMW6 H3BNT0 H3BUA8 O95180	A0A087WZL8 A0A1W2PNQ3 A0A1W2PNW6 A0A1W2PP94 A0A1W2PPY5 A0A1W2PQ61 A0A1W2PQA0 A0A1W2PQK5 A0A1W2PQU4 A0A1W2PR56 A0A1W2PR62 A0A1W2PRB0 A0A1W2PRN5 A0A1W2PSD3 B7ZMF5 D5MRH1 Q12791 Q59FH2 Q5SVJ7 Q5SVJ8 Q5SVJ9 S4R453
PDB IDs		9AYG 9AYH 9AYJ 9AYK 9AYL	2K44 3MT5 3NAF 6ND0 6V22 6V35 6V38 6V3G 6V5A 7YNZ 7YO0 7YO1 7YO2 7YO3 7YO4 7YO5 8GH9 8GHF 8GHG 8V60 8V63 8V64 8VAV 8VAZ 8Z3S 9CZH 9CZJ 9CZK 9CZM 9CZO 9CZQ 9D18 9D19 9JO3 9JO4
Enriched GO Terms of Interacting Partners?		Large Conductance Calcium-activated Potassium Channel Activity Response To Carbon Monoxide Smooth Muscle Contraction Involved In Micturition Micturition Chemokine Receptor Activity Interneuron Migration C-C Chemokine Binding C-C Chemokine Receptor Activity Tolerance Induction Calcium-activated Potassium Channel Activity Negative Regulation Of Cell Volume Urinary Bladder Smooth Muscle Contraction Intracellular Potassium Ion Homeostasis Cellular Response To Catecholamine Stimulus Cellular Response To Prostaglandin E Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Catecholamine G Protein-coupled Dopamine Receptor Signaling Pathway G-protein Beta-subunit Binding Neuron Projection Arborization
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