CACNA1H and CCR4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CACNA1H	CCR4
Description		calcium voltage-gated channel subunit alpha1 H	C-C motif chemokine receptor 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Low Voltage-gated Calcium Channel Activity Metal Ion Binding Scaffold Protein Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Monoatomic Ion Transmembrane Transport Cortisol Biosynthetic Process Cellular Response To Potassium Ion Regulation Of Membrane Potential Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Acrosome Reaction	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Homeostasis Of Number Of Cells Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interneuron Migration
Pathways		NCAM1 interactions Smooth Muscle Contraction Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Ergocalciferol Enflurane Isradipine Spironolactone Cinnarizine Nicardipine Nicardipine Verapamil Verapamil Zonisamide Felodipine Nitrendipine Nifedipine Bepridil Mibefradil Flunarizine Nilvadipine Nilvadipine Cannabidiol Trimebutine Barnidipine Aranidipine Benidipine Efonidipine Efonidipine Efonidipine Manidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols	Mogamulizumab FLX475
Diseases
GWAS		Eosinophil count ( 32888494) Leukocyte telomere length ( 32109421) Mastocytosis (KIT D816V positive) ( 33421400)	Asthma ( 31959851) Celiac disease ( 20190752 22057235) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)
Interacting Genes		3 interacting genes: CCR4 GNG2 KCNMA1	37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1
Entrez ID		8912	1233
HPRD ID		07442	05324
Ensembl ID		ENSG00000196557	ENSG00000183813
Uniprot IDs		A0A1W2PQW2 A0AAA9YHH8 B3KQH9 H3BMW6 H3BNT0 H3BUA8 O95180	A0N0Q1 P51679
PDB IDs		9AYG 9AYH 9AYJ 9AYK 9AYL
Enriched GO Terms of Interacting Partners?		Large Conductance Calcium-activated Potassium Channel Activity Response To Carbon Monoxide Smooth Muscle Contraction Involved In Micturition Micturition Chemokine Receptor Activity Interneuron Migration C-C Chemokine Binding C-C Chemokine Receptor Activity Tolerance Induction Calcium-activated Potassium Channel Activity Negative Regulation Of Cell Volume Urinary Bladder Smooth Muscle Contraction Intracellular Potassium Ion Homeostasis Cellular Response To Catecholamine Stimulus Cellular Response To Prostaglandin E Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Catecholamine G Protein-coupled Dopamine Receptor Signaling Pathway G-protein Beta-subunit Binding Neuron Projection Arborization	Calcium Ion Transport Cell Chemotaxis Chemokine Activity Leukocyte Chemotaxis Leukocyte Migration Eosinophil Migration Eosinophil Chemotaxis Beta-adrenergic Receptor Kinase Activity Granulocyte Chemotaxis Positive Regulation Of Macrophage Migration CCR Chemokine Receptor Binding Metal Ion Transport Membrane Granulocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Desensitization Of G Protein-coupled Receptor Signaling Pathway Membrane Organization Chemotaxis Endoplasmic Reticulum Tubular Network Formation CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Adaptation Of Signaling Pathway Monoatomic Ion Transport Locomotion Endoplasmic Reticulum Tubular Network Membrane Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide CCR5 Chemokine Receptor Binding Regulation Of Macrophage Migration Monoatomic Cation Transport Myeloid Leukocyte Migration Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Phospholipase Activator Activity Thyroid Hormone Transport Endoplasmic Reticulum Membrane Positive Regulation Of Transport Host-mediated Suppression Of Viral Transcription Antimicrobial Humoral Response Sarcoplasmic Reticulum Calcium Ion Transport Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Proces Cadherin Binding Macrophage Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Chemotaxis Calcium Ion Transmembrane Transport Steroid Biosynthetic Process Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Heart Contraction Regulation Of Viral Entry Into Host Cell Positive Regulation Of Neuroinflammatory Response
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