CACNA1H

Description		calcium voltage-gated channel subunit alpha1 H
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Low Voltage-gated Calcium Channel Activity Metal Ion Binding Scaffold Protein Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Muscle Contraction Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Monoatomic Ion Transmembrane Transport Cortisol Biosynthetic Process Cellular Response To Potassium Ion Regulation Of Membrane Potential Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Acrosome Reaction
Pathways		NCAM1 interactions Smooth Muscle Contraction Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs		Ergocalciferol Enflurane Isradipine Spironolactone Cinnarizine Nicardipine Nicardipine Verapamil Verapamil Zonisamide Felodipine Nitrendipine Nifedipine Bepridil Mibefradil Flunarizine Nilvadipine Nilvadipine Cannabidiol Trimebutine Barnidipine Aranidipine Benidipine Efonidipine Efonidipine Efonidipine Manidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols
Diseases
GWAS		Eosinophil count ( 32888494) Leukocyte telomere length ( 32109421) Mastocytosis (KIT D816V positive) ( 33421400)
Novel Interacting Genes		1 novel interacting genes: PAK6
Interacting Genes		3 interacting genes: CCR4 GNG2 KCNMA1
Entrez ID		8912
HPRD ID		07442
Ensembl ID		ENSG00000196557
Uniprot IDs		A0A1W2PQW2 A0AAA9YHH8 B3KQH9 H3BMW6 H3BNT0 H3BUA8 O95180
PDB IDs		9AYG 9AYH 9AYJ 9AYK 9AYL
Enriched GO Terms of Interacting Partners?		Large Conductance Calcium-activated Potassium Channel Activity Response To Carbon Monoxide Smooth Muscle Contraction Involved In Micturition Micturition Chemokine Receptor Activity Interneuron Migration C-C Chemokine Binding C-C Chemokine Receptor Activity Tolerance Induction Calcium-activated Potassium Channel Activity Negative Regulation Of Cell Volume Urinary Bladder Smooth Muscle Contraction Intracellular Potassium Ion Homeostasis Cellular Response To Catecholamine Stimulus Cellular Response To Prostaglandin E Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Catecholamine G Protein-coupled Dopamine Receptor Signaling Pathway G-protein Beta-subunit Binding Neuron Projection Arborization
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