STK19 and PRAME

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		STK19	PRAME
Gene Name		serine/threonine kinase 19	preferentially expressed antigen in melanoma
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding	Protein Binding Retinoic Acid Receptor Binding
	Biological Process	Protein Phosphorylation	Transcription, DNA-templated Apoptotic Process Positive Regulation Of Cell Proliferation Cell Differentiation Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23577725) Hematology traits ( 23263863) Prostate cancer ( 23535732)
Protein-Protein Interactions		8 interactors: BHLHE40 POLE POLR2G PRAME SF3B4 SLC29A1 SP3 TRIM23	9 interactors: CUL2 RARA RBX1 STK19 TCEB1 TCEB2 UBC XRN2 ZNF408
Entrez ID		8859	23532
HPRD ID		07281	05820
Ensembl ID		ENSG00000204344	ENSG00000185686
Uniprot IDs		P49842	F5H4B1 P78395
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Transcription-coupled Nucleotide-excision Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Uridine Transport Regulation Of MRNA Processing Nucleotide-excision Repair Pyrimidine Nucleoside Transport Cellular Metabolic Process RNA Metabolic Process Base-excision Repair, Gap-filling Transcription From RNA Polymerase II Promoter Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Embryonic Process Involved In Female Pregnancy Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Initiation Enucleate Erythrocyte Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Granulocyte Differentiation Sleep DNA Synthesis Involved In DNA Repair RNA Splicing Nucleotide-excision Repair, DNA Gap Filling Regulation Of MRNA 3'-end Processing Nucleoside Transmembrane Transport Monocyte Differentiation Nucleoside Transport Natural Killer Cell Differentiation Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of MRNA Catabolic Process Regulation Of RNA Metabolic Process Megakaryocyte Differentiation Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gene Expression Definitive Hemopoiesis Nuclear DNA Replication Telomere Maintenance Via Recombination Negative Regulation Of Biosynthetic Process	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Hypoxia Viral Process Cellular Macromolecule Catabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Abiotic Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Stress Positive Regulation Of Viral Transcription Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Catabolic Process Transcription Elongation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Sertoli Cell Fate Commitment DNA-templated Transcription, Elongation Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Gene Expression Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Notch Signaling Pathway
Tagcloud ?		acral amine awareness braf causative ctla4 dabrafenib etc exceptionally grin2a holds imatinib immunosuppressive instances mandatory mek melanoma melanomas nevertheless nras ppp6c prex2 rac1 revolution substitutions threonine trrap ultraviolet vemurafenib	aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing ref tab trp tyrosinase uncloned
Tagcloud (Difference) ?		acral amine awareness braf causative ctla4 dabrafenib etc exceptionally grin2a holds imatinib immunosuppressive instances mandatory mek melanoma nevertheless nras ppp6c prex2 rac1 revolution substitutions threonine trrap ultraviolet vemurafenib	aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte p15 pbl permitted pointing ref tab trp tyrosinase uncloned
Tagcloud (Intersection) ?		melanomas