POLE and EIF2B1

		POLE	EIF2B1
Description		DNA polymerase epsilon, catalytic subunit	eukaryotic translation initiation factor 2B subunit alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' DNA Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication Leading Strand Elongation DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response DNA Replication Proofreading Embryonic Organ Development DNA Biosynthetic Process	Cytoplasmic Translational Initiation Translation Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone T Cell Receptor Signaling Pathway
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Recycling of eIF2:GDP
Drugs		Cladribine
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)	Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: ABHD16A CFTR CLSPN GINS4 MDM2 PCNA POLA1 POLD4 POLE4 RAD17 TOPBP1 WHR1 XRCC5	21 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 RD3 TRIM59 TRIML2 UBE2I
Entrez ID		5426	1967
HPRD ID		07177	09458
Ensembl ID		ENSG00000177084	ENSG00000111361
Uniprot IDs		Q07864	Q14232
PDB IDs		5VBN 7PFO 7PLO 9B8S 9B8T 9F6D 9F6E 9F6F 9F6I 9F6J 9F6K 9F6L	3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMA 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQZ
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Response To Stress DNA Damage Response Cellular Response To Stress DNA Biosynthetic Process Mitotic DNA Replication Checkpoint Signaling DNA-templated DNA Replication DNA Replication DNA Replication Checkpoint Signaling DNA-directed DNA Polymerase Activity Nucleic Acid Metabolic Process Leading Strand Elongation DNA Synthesis Involved In DNA Repair Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage Male Germ Cell Nucleus Mitotic G2/M Transition Checkpoint Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Strand Elongation Involved In DNA Replication Double-strand Break Repair Protein-containing Complex Chromatin-protein Adaptor Activity DNA Damage Checkpoint Signaling Response To Lipid DNA Strand Elongation Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Cell Cycle G2/M Phase Transition Nucleoplasm Protein Localization To Site Of Double-strand Break DNA Replication Initiation Cellular Response To Gamma Radiation Recycling Endosome Regulation Of Mitotic Cell Cycle Phase Transition Recombinational Repair Response To Hormone Response To Ionizing Radiation Chromosome Organization Protein-containing Complex Binding Protein Localization To Organelle Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity	Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Adrenergic Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Regulation Of Norepinephrine Secretion Negative Regulation Of Catecholamine Secretion Regulation Of Smooth Muscle Contraction Norepinephrine Binding Eukaryotic Translation Initiation Factor 2 Complex Regulation Of Catecholamine Secretion Translation Initiation Factor Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Uterine Smooth Muscle Contraction Regulation Of Muscle Contraction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Smooth Muscle Contraction ERBB Signaling Pathway Regulation Of Amine Transport Translational Initiation Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of Muscle Contraction Vascular Process In Circulatory System Regulation Of Translational Initiation Circulatory System Process Cytoplasmic Translational Initiation Negative Regulation Of Insulin Secretion Negative Regulation Of Secretion By Cell G Protein-coupled Receptor Activity Negative Regulation Of Uterine Smooth Muscle Contraction Alpha-1B Adrenergic Receptor Binding Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Temperature Stimulus Translation Initiation Ternary Complex Translation SUMO Conjugating Enzyme Activity Carbohydrate Phosphatase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Guanylate Cyclase Activity Negative Regulation Of Secretion Negative Regulation Of Peptide Secretion Macromolecule Biosynthetic Process Protein Metabolic Process
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