EIF2B1 and EIF2S2

Number of citations of the paper that reports this interaction (PubMedID 9446619)
0

Data Source:
HPRD (in vitro)

		EIF2B1	EIF2S2
Description		eukaryotic translation initiation factor 2B subunit alpha	eukaryotic translation initiation factor 2 subunit beta
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex Synapse
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Zinc Ion Binding Translation Initiation Factor Binding Metal Ion Binding
	Biological Process	Cytoplasmic Translational Initiation Translation Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone T Cell Receptor Signaling Pathway	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Male Germ Cell Proliferation Cytoplasmic Translational Initiation Translation Translational Initiation Male Gonad Development
Pathways		Recycling of eIF2:GDP	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Refractive error ( 32231278) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)
Interacting Genes		21 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D ATF5 BZW2 C1orf50 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MED29 MRPL4 NTAQ1 RD3 TRIM59 TRIML2 UBE2I	25 interacting genes: APLP1 APP CCDC90B CEBPA CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 NCK1 OGT PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16
Entrez ID		1967	8894
HPRD ID		09458	04882
Ensembl ID		ENSG00000111361	ENSG00000125977
Uniprot IDs		Q14232	P20042 Q6IBR8
PDB IDs		3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMA 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQZ	6K71 6K72 6YBV 6ZMW 6ZP4 7A09 7D43 7QP6 8OZ0 8PJ1 8PPL
Enriched GO Terms of Interacting Partners?		Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Adrenergic Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Regulation Of Norepinephrine Secretion Negative Regulation Of Catecholamine Secretion Regulation Of Smooth Muscle Contraction Norepinephrine Binding Eukaryotic Translation Initiation Factor 2 Complex Regulation Of Catecholamine Secretion Translation Initiation Factor Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Uterine Smooth Muscle Contraction Regulation Of Muscle Contraction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Smooth Muscle Contraction ERBB Signaling Pathway Regulation Of Amine Transport Translational Initiation Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of Muscle Contraction Vascular Process In Circulatory System Regulation Of Translational Initiation Circulatory System Process Cytoplasmic Translational Initiation Negative Regulation Of Insulin Secretion Negative Regulation Of Secretion By Cell G Protein-coupled Receptor Activity Negative Regulation Of Uterine Smooth Muscle Contraction Alpha-1B Adrenergic Receptor Binding Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Temperature Stimulus Translation Initiation Ternary Complex Translation SUMO Conjugating Enzyme Activity Carbohydrate Phosphatase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Negative Regulation Of Guanylate Cyclase Activity Negative Regulation Of Secretion Negative Regulation Of Peptide Secretion Macromolecule Biosynthetic Process Protein Metabolic Process	Translation Initiation Factor Activity Regulation Of Translation Eukaryotic Translation Initiation Factor 2B Complex Translational Initiation Regulation Of Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Glial Cell Development Translation Oligodendrocyte Development Central Nervous System Development Cytoplasmic Translational Initiation Response To Heat T Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Response To Glucose Signal Transduction Transcription Regulator Complex Cytosol Response To Monosaccharide Cell Surface Receptor Signaling Pathway Response To Hormone Response To Temperature Stimulus Antigen Receptor-mediated Signaling Pathway Response To Carbohydrate Protein-containing Complex Organization Cell Development Regulation Of Apoptotic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Eukaryotic Initiation Factor EIF2 Binding Macromolecule Biosynthetic Process Response To Peptide Hormone Molecular Function Activator Activity Cell Death Cellular Response To Norepinephrine Stimulus Macromolecule Metabolic Process Response To Norepinephrine Protein-containing Complex Assembly Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Programmed Cell Death Regulation Of Proteolysis Protein Domain Specific Binding PML Body Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process B Cell Lineage Commitment
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?