EIF2B1 and ADRA2C

Number of citations of the paper that reports this interaction (PMID 9235896)
9

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		EIF2B1	ADRA2C
Gene Name		eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	adrenoceptor alpha 2C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane Axon Terminus
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding GDP Binding Enzyme Regulator Activity S-methyl-5-thioribose-1-phosphate Isomerase Activity	Alpha2-adrenergic Receptor Activity Protein Binding Alpha-2A Adrenergic Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Negative Regulation Of Translational Initiation In Response To Stress Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Blood Coagulation Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Vasoconstriction Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Negative Regulation Of Uterine Smooth Muscle Contraction Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Integration of energy metabolism Adrenaline signalling through Alpha-2 adrenergic receptor Class A/1 (Rhodopsin-like receptors) Regulation of insulin secretion Amine ligand-binding receptors Platelet Aggregation (Plug Formation) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Adrenaline,noradrenaline inhibits insulin secretion GPCR downstream signaling Adrenoceptors G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs			Bethanidine Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Norepinephrine Pramipexole Brimonidine Clonidine Lisuride Tizanidine Apomorphine Risperidone Fenoldopam Phenoxybenzamine Doxepin Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Yohimbine Methotrimeprazine Methamphetamine Dronedarone Iloperidone Asenapine Droxidopa Xylometazoline Lurasidone Agmatine
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D CREBBP EIF2B2 EIF2B5 EIF2S1 EIF2S2 GORASP2 MRPL4 RD3 WDYHV1	5 interactors: EIF2B1 GNAO1 PPP1R9B UCHL1 YWHAZ
Entrez ID		1967	152
HPRD ID		09458	00085
Ensembl ID			ENSG00000184160
Uniprot IDs		Q14232	P18825 Q4W594
PDB IDs		3ECS
Enriched GO Terms of Interacting Partners?		Adrenergic Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Receptor Transactivation Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Regulation Of Smooth Muscle Contraction Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Norepinephrine Secretion Negative Regulation Of Smooth Muscle Contraction Translational Initiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Negative Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase B Activity Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Muscle Contraction Positive Regulation Of Receptor Activity Response To Temperature Stimulus Regulation Of Vasoconstriction Positive Regulation Of Protein Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Hormone Secretion Regulation Of Translational Initiation Positive Regulation Of Catalytic Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Translational Initiation In Response To Stress Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Translation Regulation Of Translation In Response To Stress Response To Heat Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Reproductive Process Regulation Of Kinase Activity Activation Of MAPK Activity Positive Regulation Of Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Negative Regulation Of Secretion By Cell	Response To Morphine Neurogenesis Response To Ammonium Ion Cell Development Response To Alkaloid Neuron Projection Development Response To Organonitrogen Compound Regulation Of Opioid Receptor Signaling Pathway Nervous System Development Regulation Of Catalytic Activity Cellular Response To Morphine Neuron Development Golgi Reassembly Axon Target Recognition Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Locomotory Behavior Axon Transport Of Mitochondrion Neuron Differentiation Cell Projection Organization Histamine Secretion By Mast Cell Negative Regulation Of Translational Initiation In Response To Stress Establishment Of Golgi Localization Golgi Inheritance Negative Regulation Of Translation In Response To Stress Histamine Secretion Cell Differentiation Response To Stress Regulation Of Translational Initiation In Response To Stress Histamine Transport Regulation Of Exit From Mitosis Generation Of Neurons Golgi Localization Regulation Of Translation In Response To Stress Filopodium Assembly Negative Regulation Of Translational Initiation Mast Cell Degranulation System Development Cellular Response To Ammonium Ion Response To Drug Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Response To Stimulus Regulation Of Cellular Protein Metabolic Process Mast Cell Mediated Immunity Lysosome Localization Behavior Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Eating Behavior Mast Cell Activation
Tagcloud ?		1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm	16r acs adrb1 adrb2 adrenergic african americans bb blockade caucasian caucasians differently differs discharged genotype genotyped gg grk5 hazards homozygous illuminate opportunities overcoming polymorphisms race racial rg strategic stratified
Tagcloud (Difference) ?		1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm	16r acs adrb1 adrb2 adrenergic african americans bb blockade caucasian caucasians differently differs discharged genotype genotyped gg grk5 hazards homozygous illuminate opportunities overcoming polymorphisms race racial rg strategic stratified
Tagcloud (Intersection) ?