SEPT8 and SEPT5

Number of citations of the paper that reports this interaction (PMID 12023038)
4

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SEPT8	SEPT5
Gene Name		septin 8	septin 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton	Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Terminal Bouton
	Molecular Function	Protein Binding GTP Binding	GTPase Activity Structural Molecule Activity Protein Binding GTP Binding
	Biological Process	Cell Cycle	Cytokinesis Metabolic Process Synaptic Vesicle Targeting Regulation Of Exocytosis Regulation Of Synaptic Vesicle Exocytosis
Pathways
Drugs
Diseases
GWAS			DNA methylation (parent-of-origin) ( 23725790)
Protein-Protein Interactions		9 interactors: A2M CDK14 JADE1 KMT2B PPHLN1 SEPT4 SEPT5 SH3GL1 SH3GL3	18 interactors: APP KAT7 LSM8 MAGEA2B MAPK6 MYOG PARK2 PFN2 SEPT1 SEPT10 SEPT11 SEPT2 SEPT4 SEPT6 SEPT7 SEPT8 STX1A STX4
Entrez ID		23176	5413
HPRD ID		12228	04100
Ensembl ID		ENSG00000164402	ENSG00000184702
Uniprot IDs		A6NFQ9 B7ZVZ1 F6W7K9 Q92599	G3XAH0 Q99719
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Division Sperm Mitochondrion Organization Negative Regulation Of Complement Activation, Lectin Pathway	Cell Cycle Cell Division Regulation Of Synaptic Vesicle Transport Regulation Of Neurotransmitter Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Synaptic Transmission Positive Regulation Of Protein Ubiquitination Regulation Of Vesicle-mediated Transport Regulation Of Neurotransmitter Levels Regulation Of Exocytosis Neurotransmitter Transport Regulation Of Synaptic Vesicle Exocytosis Regulation Of Insulin Secretion Regulation Of Protein Ubiquitination Regulation Of Peptide Hormone Secretion Vesicle Fusion Synaptic Vesicle Exocytosis Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Muscle Atrophy Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Hormone Secretion Positive Regulation Of Exocytosis Organelle Organization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Secretion Organelle Fusion Sperm Mitochondrion Organization Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Synaptic Growth At Neuromuscular Junction Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Embryonic Cell Shape Positive Regulation Of Protein Metabolic Process Vesicle Docking Cellular Component Assembly Exocytosis Regulation Of Cellular Component Organization Membrane Docking Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Dopamine Uptake Involved In Synaptic Transmission Collateral Sprouting In Absence Of Injury Regulation Of Protein Localization Regulation Of Protein Secretion Cytokinesis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of L-glutamate Transport Neurotransmitter Secretion
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