BRWD1 and SMARCA4

Number of citations of the paper that reports this interaction (PMID 12889071)
8

Data Source:
HPRD (in vivo, in vitro)

		BRWD1	SMARCA4
Gene Name		bromodomain and WD repeat domain containing 1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Nuclear Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Nucleolus Membrane SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex
	Molecular Function	Molecular_function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Tat Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding Androgen Receptor Binding DNA Polymerase Binding Lysine-acetylated Histone Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cytoskeleton Organization Regulation Of Cell Shape	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Vasculogenesis Blastocyst Growth Blastocyst Hatching Liver Development Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Methylation-dependent Chromatin Silencing Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Glial Cell Fate Determination DNA Methylation On Cytosine Within A CG Sequence Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Keratinocyte Differentiation Negative Regulation Of Cell Growth Forebrain Development Hindbrain Development Embryonic Hindlimb Morphogenesis Aortic Smooth Muscle Cell Differentiation ATP-dependent Chromatin Remodeling Positive Regulation Of DNA Binding Positive Regulation By Host Of Viral Transcription Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Epidermis Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Definitive Erythrocyte Differentiation Heart Trabecula Formation Negative Regulation Of Androgen Receptor Signaling Pathway Lens Fiber Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer RMTs methylate histone arginines
Drugs
Diseases
GWAS		Temperament (bipolar disorder) ( 22365631)	Coronary heart disease ( 21347282)
Protein-Protein Interactions		3 interactors: APP CALM1 SMARCA4	73 interactors: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHMP5 CIITA CREB1 CTNNB1 DPF3 ESR1 ETS2 FANCA GATA1 GMNN H2AFX H3F3A HIST1H3A HIST1H4F HIST2H2BE HIST2H3C HSF1 HSF4 IKZF1 KLF1 MBD3 MDM2 MED17 MED6 MKL1 MPHOSPH6 MPP6 MYC MYOCD NR3C1 NR4A2 PABPN1 PAX6 PBRM1 PHB RAP1A RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SS18 SS18L1 STAT2 STAT3 STK11 TMF1 TP53 ZMYND11
Entrez ID		54014	6597
HPRD ID		11683	04459
Ensembl ID		ENSG00000185658	ENSG00000127616
Uniprot IDs		Q9NSI6	A7E2E1 B3KNW7 P51532 Q9HBD4
PDB IDs		3Q2E	2GRC 2H60 3UVD
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Process Platelet Degranulation Brain Development Head Development Regulation Of Cell Cycle Central Nervous System Development Platelet Activation Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Synaptic Growth At Neuromuscular Junction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Biosynthetic Process Collateral Sprouting In Absence Of Injury Regulation Of Binding Developmental Growth DNA Methylation On Cytosine Within A CG Sequence Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of High Voltage-gated Calcium Channel Activity Response To Light Stimulus Exocytosis Alcohol Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Definitive Erythrocyte Differentiation Aortic Smooth Muscle Cell Differentiation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Cellular Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Immune System Process Axon Choice Point Recognition Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Mitotic Cell Cycle Methylation-dependent Chromatin Silencing Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Glial Cell Fate Determination Nervous System Development Blood Coagulation Hemostasis Forebrain Development Response To Radiation Neuron Remodeling Positive Regulation By Host Of Viral Transcription Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Growth Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Cellular Metabolic Process Secretion By Cell Detection Of Calcium Ion	Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Organelle Organization Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Anatomical Structure Development Developmental Process Chromatin Assembly Or Disassembly System Development Multicellular Organismal Development ATP-dependent Chromatin Remodeling
Tagcloud ?			abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Difference) ?			abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Intersection) ?