BRWD1 and FNDC3B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BRWD1	FNDC3B
Description		bromodomain and WD repeat domain containing 1	fibronectin type III domain containing 3B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Motile Cilium Cell Projection Ciliary Membrane	Cytoplasm Endomembrane System Membrane
	Molecular Function	Protein Binding	RNA Binding Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Cell Shape
Pathways		Interleukin-7 signaling Interleukin-7 signaling Chromatin modifying enzymes
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Apolipoprotein B levels ( 32203549) Cognitive function ( 25644384) Daytime nap ( 33568662) Daytime sleep phenotypes ( 27126917) General cognitive ability ( 29844566) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Menarche (age at onset) ( 25231870) Platelet distribution width ( 32888494) Smoking initiation ( 33082346) Temperament (bipolar disorder) ( 22365631) Total cholesterol levels ( 30275531)	Appendicular lean mass ( 33097823) Bell's palsy ( 33602968) Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal hysteresis ( 30894546) Corneal resistance factor ( 30894546 31246245) Corneal structure ( 23291589) Coronary artery disease ( 33020668 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 33627673) Glycated hemoglobin levels ( 34059833 28898252) Heart rate ( 23583979) Height ( 31562340 33713608 23563607 28552196 25282103 25429064) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 25173106 31798171 28073927 29785010 30054594 29617998 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Keratoconus ( 33649486) Mean corpuscular hemoglobin ( 32888494) Myocardial infarction ( 33532862) Parkinson's disease ( 26227905) PR interval ( 32439900) Pulse pressure ( 30224653) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triptolide cytotoxicity ( 26121980) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		18 interacting genes: APP APPL1 CALM1 COPS5 CUL4B FNDC3B HDAC7 HIVEP2 NRF1 NUTF2 PPP5C SMARCA4 SMARCD1 STAT3 SYT4 TAF1 TRIM55 TRIM63	124 interacting genes: ABHD11 ABHD8 ACTG1 ACTMAP ADGRF5 AHNAK ALB ANXA2 ATP1A1 ATP5F1A BBS2 BICRAL BRWD1 C10orf55 C22orf15 CAMK2D CAP1 CAPN3 CDC42 CEMP1 CFL1 DAPL1 DSTN DUSP10 EEF1E1 EGFR EIF5A2 ENO1 ERCC6 ERH ERI3 FUS GAS2L3 GOLT1B GTF2F1 HAPLN2 HNRNPD HNRNPK HSP90AB4P HSPA1A HSPA5 HSPA7 HSPA8 HSPB1 HSPD1 HSPH1 KARS1 KLHDC7B KRTAP11-1 L3MBTL3 LARP4 MBD3L1 MBOAT7 MCCD1 MVP MYH14 MYL6 NAGK NCAM2 NCK1 NDUFAB1 P4HB PARP1 PC PGK1 PIK3R4 PKLR POGZ POU6F2 PPP6R2 PRKAA2 PSMA3 PTMA RAB1A RAB1B RAN REL RPL12 RPL15 RPL17 RPL23 RPL28 RPL34 RPS14 RPS3 RPS3A RPS6 RUSC1 SNRPD3 SOD1 SPCS2 SPMIP10 SPMIP5 SPSB2 SRARP STPG4 SUGT1 SUOX SYNCRIP TEKT5 TEPSIN TESMIN TEX48 TGM2 TIAM1 TKT TOX4 TPM3 TRAF2 TRIM16 TRIM35 TRIM42 TRIP13 TTN TUBB4A TUBGCP6 TXN UBA52 UBAP2 USP54 VAC14 YPEL3 YWHAZ ZMYND19
Entrez ID		54014	64778
HPRD ID		11683	10943
Ensembl ID		ENSG00000185658	ENSG00000075420
Uniprot IDs		Q9NSI6	Q53EP0
PDB IDs		3Q2E
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Gene Expression, Epigenetic Regulation Of Glycolytic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of ATP Metabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Signaling Astrocyte Projection Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Cell Cycle Process Titin Binding Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Cell Differentiation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway NBAF Complex RSC-type Complex NpBAF Complex Regulation Of Cell Cycle Phase Transition GBAF Complex Protein Modification By Small Protein Conjugation Response To Lead Ion Modulation Of Chemical Synaptic Transmission Regulation Of Non-canonical NF-kappaB Signal Transduction Nucleosome Disassembly Negative Regulation Of Glycolytic Process Epigenetic Regulation Of Gene Expression Neuronal Dense Core Vesicle Protein-DNA Complex Disassembly Post-translational Protein Modification Regulation Of Cellular Response To Stress Protein Import Into Nucleus Negative Regulation Of ATP Metabolic Process Regulation Of Endocytosis Nucleoplasm Import Into Nucleus Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Nucleotide-excision Repair Negative Regulation Of Developmental Process	Extracellular Exosome Cytosol Cytoplasm Cytoplasmic Translation Cytosolic Ribosome Focal Adhesion Ribonucleoprotein Complex RNA Binding ATP-dependent Protein Folding Chaperone Translation Structural Constituent Of Ribosome Ribosome Protein Refolding Cadherin Binding Cytosolic Large Ribosomal Subunit Protein-containing Complex Melanosome Protein Binding Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding ATP Metabolic Process Protein Metabolic Process Protein Phosphatase Binding Cytosolic Small Ribosomal Subunit Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding Nucleotide Binding Response To Nitric Oxide Protein Folding Positive Regulation Of Protein Metabolic Process Organophosphate Metabolic Process Enzyme Binding Actin Filament-based Process Macromolecule Metabolic Process Nucleotide Metabolic Process Nucleus Vesicle Structural Molecule Activity Conferring Elasticity Purine Nucleotide Metabolic Process Protein Folding Chaperone Nucleobase-containing Small Molecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway ATP Binding Positive Regulation Of Gene Expression Nicotinamide Nucleotide Metabolic Process Unfolded Protein Binding Nucleoside Phosphate Metabolic Process Cellular Response To Nitric Oxide
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