BRWD1 and HIVEP2

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		BRWD1	HIVEP2
Name		bromodomain and WD repeat domain containing 1	HIVEP zinc finger 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Motile Cilium Cell Projection Ciliary Membrane	Nucleus Nucleoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Cell Shape	Regulation Of Transcription By RNA Polymerase II
Pathways		Interleukin-7 signaling Interleukin-7 signaling Chromatin modifying enzymes	None
GWAS		Adult body size ( 32376654 ) Age at first sexual intercourse ( 34211149 ) Alanine aminotransferase levels ( 33547301 ) Apolipoprotein B levels ( 32203549 ) Cognitive function ( 25644384 ) Daytime nap ( 33568662 ) Daytime sleep phenotypes ( 27126917 ) General cognitive ability ( 29844566 ) LDL cholesterol ( 30275531 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Menarche (age at onset) ( 25231870 ) Platelet distribution width ( 32888494 ) Smoking initiation ( 33082346 ) Temperament (bipolar disorder) ( 22365631 ) Total cholesterol levels ( 30275531 )	Adiponectin levels ( 24105470 ) Adult body size ( 32376654 ) Adverse response to inhaled corticosteroid treatment x age interaction in asthma ( 32119686 ) Age at first birth ( 34211149 ) Asthma ( 32296059 ) Bipolar disorder ( 31043756 ) Coronary artery disease ( 29212778 ) Daytime sleep phenotypes ( 27126917 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Gastroesophageal reflux disease ( 34187846 ) HDL cholesterol levels ( 32203549 ) Hemoglobin ( 32888494 ) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391 ) Mood instability ( 31168069 ) Pit-and-Fissure caries ( 24556642 ) Platelet distribution width ( 32888494 ) Type 2 diabetes ( 32499647 ) Weight ( 28552196 )
Novel Interactors		2 novel interactors: ADD2 EIF4E	1 novel interactors: PAX6
Interacting Genes		18 interacting genes: APP APPL1 CALM1 COPS5 CUL4B FNDC3B HDAC7 HIVEP2 NRF1 NUTF2 PPP5C SMARCA4 SMARCD1 STAT3 SYT4 TAF1 TRIM55 TRIM63	8 interacting genes: BRWD1 BTG3 CREBBP LINC01554 MTNR1A RFX1 RSPH1 YWHAE
Entrez ID		54014	3097
HPRD ID		11683	00881
Ensembl ID		ENSG00000185658	ENSG00000010818
Uniprot IDs		Q9NSI6	P31629
PDB IDs		3Q2E	Not available
GO Terms Enriched among Interactors		Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Gene Expression, Epigenetic Regulation Of Glycolytic Process Regulation Of Mitotic Cell Cycle Nucleus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of ATP Metabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Signaling Astrocyte Projection Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Cell Cycle Process Titin Binding Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Cell Differentiation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway NBAF Complex RSC-type Complex NpBAF Complex Regulation Of Cell Cycle Phase Transition GBAF Complex Protein Modification By Small Protein Conjugation Response To Lead Ion Modulation Of Chemical Synaptic Transmission Regulation Of Non-canonical NF-kappaB Signal Transduction Nucleosome Disassembly Negative Regulation Of Glycolytic Process Epigenetic Regulation Of Gene Expression Neuronal Dense Core Vesicle Protein-DNA Complex Disassembly Post-translational Protein Modification Regulation Of Cellular Response To Stress Protein Import Into Nucleus Negative Regulation Of ATP Metabolic Process Regulation Of Endocytosis Nucleoplasm Import Into Nucleus Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Nucleotide-excision Repair Negative Regulation Of Developmental Process	None