DDX39A and CCL14

Number of citations of the paper that reports this interaction (PubMedID 15338056)
41

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		DDX39A	CCL14
Description		DExD-box helicase 39A	C-C motif chemokine ligand 14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Speck	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding	Cytokine Activity Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	MRNA Splicing, Via Spliceosome Toll-like Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing Negative Regulation Of Innate Immune Response Negative Regulation Of RNA Export From Nucleus	Intracellular Calcium Ion Homeostasis Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Blood protein levels ( 30072576) Metabolite levels ( 23823483) Upper eyelid sagging severity ( 24869959)
Interacting Genes		14 interacting genes: CCL14 CEBPA DDX39B EXOSC9 HIPK2 HNRNPLL PTK2 RNF4 SARNP SAT1 SUMO2 TERF1 TERF2IP UBE2I	12 interacting genes: ACKR2 AKT2 CCL11 CCL22 CCR1 CCR3 CCR5 DDX39A EXOSC8 NOA1 PIK3R1 RBPMS
Entrez ID		10212	6358
HPRD ID		10861	03231
Ensembl ID		ENSG00000123136	ENSG00000276409
Uniprot IDs		O00148	Q16627
PDB IDs		8IJU	2Q8R 2Q8T
Enriched GO Terms of Interacting Partners?		PML Body Regulation Of Ubiquitin-dependent Protein Catabolic Process Nuclear Body Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping G-rich Strand Telomeric DNA Binding Transcription Export Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process SUMO Transferase Activity RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Nuclear Export Regulation Of Proteolysis Nucleus Nuclear Chromosome Presynaptic Cytosol Postsynaptic Cytosol Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Protein Metabolic Process RNA Binding Spermidine Binding Protein Sumoylation Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly SUMO Conjugating Enzyme Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Regulation Of Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Chemokine-mediated Signaling Pathway Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cell Chemotaxis Cytokine-mediated Signaling Pathway Chemotaxis Locomotion Intracellular Signal Transduction Leukocyte Migration Chemokine (C-C Motif) Ligand 5 Binding Intracellular Signaling Cassette Cell Migration Inflammatory Response Myeloid Leukocyte Migration Cell Motility Leukocyte Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Immune Response G Protein-coupled Receptor Signaling Pathway Immune System Process Cell Surface Receptor Signaling Pathway Defense Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Signal Transduction Dendritic Cell Chemotaxis External Side Of Plasma Membrane Eosinophil Chemotaxis G Protein-coupled Receptor Activity Eosinophil Migration Dendritic Cell Migration Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity CCR Chemokine Receptor Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Cell Killing Response To Stress Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of D-glucose Transmembrane Transport Response To Cytokine Response To Peptide Regulation Of Locomotion Chemokine Activity Cellular Defense Response Cellular Response To High Light Intensity Regulation Of Biological Quality
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