DDX39A and RNF4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DDX39A	RNF4
Description		DExD-box helicase 39A	ring finger protein 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Toll-like Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing Negative Regulation Of Innate Immune Response Negative Regulation Of RNA Export From Nucleus	DNA Damage Response Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly Negative Regulation Of Protein Localization To Chromatin
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)
Interacting Genes		14 interacting genes: CCL14 CEBPA DDX39B EXOSC9 HIPK2 HNRNPLL PTK2 RNF4 SARNP SAT1 SUMO2 TERF1 TERF2IP UBE2I	141 interacting genes: AIM2 AKAP17A AR ARID3C ARK2N ATF2 ATXN1 BCL2L1 BIRC6 BLM BTBD1 BTBD3 C14orf119 CAMK2B CAMK2D CCL2 CFL2 CREB1 DAXX DDX39A DDX39B DES DESI1 EHHADH EIF2A ESR1 ESRRA FADD FAM118A FAM9A FKBP6 GMCL1 GSC2 H3C14 HGS HMGA1 HNF4A HNRNPCL1 HNRNPCL2 HNRNPH1 HNRNPK ID1 IKBKG IKZF1 IMPDH1 KLHL12 LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3B LCE5A LXN MYD88 NKX3-1 NMNAT1 NTAQ1 NVL PAICS PARP1 PATZ1 PCBP3 PGR PHC1 PRMT5 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8 RHOXF2 RUNX1T1 SCML2 SEPTIN3 SKIL SNAPC5 SOX5 SP1 SRPK2 SSNA1 STX1A STX2 STX4 SUMO1 SUMO2 TBP TCF20 TERF2 TFG THAP1 TOP2B TRAF2 TRAF3 TRAF4 TRAF5 TRAIP TRIM28 TRIM38 TRIM54 TRIP13 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UBQLN1 UBQLN2 UBTD2 UCHL1 UCHL5 UEVLD VENTX ZBTB26 ZBTB34 ZBTB6 ZC3H10 ZCCHC17 ZFP42 ZNF275 ZNF319 ZNF696 ZNF792 ZNRD2
Entrez ID		10212	6047
HPRD ID		10861	04167
Ensembl ID		ENSG00000123136	ENSG00000063978
Uniprot IDs		O00148	P78317
PDB IDs		8IJU	2EA6 2XEU 4PPE
Enriched GO Terms of Interacting Partners?		PML Body Regulation Of Ubiquitin-dependent Protein Catabolic Process Nuclear Body Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping G-rich Strand Telomeric DNA Binding Transcription Export Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process SUMO Transferase Activity RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Nuclear Export Regulation Of Proteolysis Nucleus Nuclear Chromosome Presynaptic Cytosol Postsynaptic Cytosol Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Protein Metabolic Process RNA Binding Spermidine Binding Protein Sumoylation Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly SUMO Conjugating Enzyme Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Regulation Of Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Identical Protein Binding Ubiquitin Conjugating Enzyme Activity Nucleus Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Ubiquitin-protein Transferase Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process DNA Binding Chromatin Regulation Of Transcription By RNA Polymerase II Keratinization Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Monoubiquitination Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein-containing Complex DNA Damage Response Positive Regulation Of Metabolic Process Signaling Adaptor Activity Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Nucleic Acid Metabolic Process Thioesterase Binding
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