ATP5PO and NDC80

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		ATP5PO	NDC80
Name		ATP synthase peripheral stalk subunit OSCP	NDC80 kinetochore complex component
Structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Plasma Membrane Cell Surface Membrane Proton-transporting ATP Synthase Complex	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Membrane Nuclear Speck Ndc80 Complex
	Molecular Function	Protein Binding ATP Hydrolysis Activity Protein-containing Complex Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Estradiol Binding	Protein Binding Microtubule Binding Cyclin Binding Identical Protein Binding Kinetochore Adaptor Activity
	Biological Process	ATP Biosynthetic Process Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Cellular Response To CAMP Cellular Response To Cytokine Stimulus Proton Transmembrane Transport	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Nuclear Division Spindle Organization Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling G2/MI Transition Of Meiotic Cell Cycle Attachment Of Spindle Microtubules To Kinetochore Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Stability Chromosome Organization Centrosome Duplication Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Nuclear Chromosome Segregation
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation Mitochondrial protein degradation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Artenimol	None
GWAS		No GWAS studies recorded	Metabolite levels ( 23823483 ) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309 )
Novel Interactors		2 novel interactors: CBR3 RCAN1	2 novel interactors: HPCA MX1
Interacting Genes		19 interacting genes: APP CCDC136 CEP70 ERCC6 GOLGA2 HMBOX1 KRT13 KRT15 MIPOL1 NDC80 NME6 NT5C2 PNMA1 TEX13A TFIP11 TRIP6 USHBP1 ZBTB14 ZNF76	57 interacting genes: AMOTL2 ATF4 ATP5PO ATP6V1D AURKA AURKB BLOC1S6 CAGE1 CALCOCO1 CCDC136 CCHCR1 CCNH CCNK CEP63 CIP2A CKAP5 EXOC8 GOLGA2 HAUS1 HGS IFT20 INPP1 KIFC3 KLC3 KLHL12 KRT27 KRT6B KRT75 LNX1 MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PPP1R13B PSMC2 RB1 SFR1 SKA1 SKA3 SMC1A SPC25 STX11 TFIP11 THOC7 TOM1L1 TXLNA USHBP1 VPS52 WASHC1 WASHC3 ZNF655 ZWINT
Entrez ID		539	10403
HPRD ID		02899	06277
Ensembl ID		ENSG00000241837	ENSG00000080986
Uniprot IDs		P48047	A8K031 O14777
PDB IDs		8H9E 8H9I 8H9L 8H9P 8H9S 8H9T 8H9U 8H9V 8KI3	2IGP 2VE7 3IZ0 8G0P
GO Terms Enriched among Interactors		Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Kinetochore Cell Division Chromosome, Centromeric Region Organelle Organization Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Spindle Organization Attachment Of Spindle Microtubules To Kinetochore Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Centrosome Regulation Of Chromosome Separation Negative Regulation Of Cell Cycle Process Nuclear Chromosome Segregation Microtubule-based Process Negative Regulation Of Cell Cycle Microtubule Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Mitotic Sister Chromatid Segregation Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Sister Chromatid Segregation Regulation Of Sister Chromatid Segregation Spindle Pole Cytoskeleton Organization Regulation Of Chromosome Segregation Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Chromosome Spindle Regulation Of Chromosome Organization Positive Regulation Of Mitotic Sister Chromatid Separation Organelle Assembly Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Binding Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Cell Cycle Process Microtubule Chromosome Organization Membraneless Organelle Assembly Cytoskeleton Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cell Cycle