ASGR2 and SLC35B2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ASGR2	SLC35B2
Name		asialoglycoprotein receptor 2	solute carrier family 35 member B2
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Membrane
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Fucose Binding	Protein Binding Antiporter Activity 3'-phosphoadenosine 5'-phosphosulfate Transmembrane Transporter Activity
	Biological Process	Endocytosis Immune Response Cell Surface Receptor Signaling Pathway	Positive Regulation Of Canonical NF-kappaB Signal Transduction 3'-phosphoadenosine 5'-phosphosulfate Transport Chondroitin Sulfate Proteoglycan Biosynthetic Process Transmembrane Transport 5'-adenylyl Sulfate Transmembrane Transport 3'-phospho-5'-adenylyl Sulfate Transmembrane Transport
Pathways		Asparagine N-linked glycosylation	Transport and metabolism of PAPS Transport of nucleotide sugars
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa	None
GWAS		Congenital heart disease (maternal effect) ( 28468790 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Total cholesterol levels ( 30275531 )	Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		50 interacting genes: ADAM33 ADIPOQ AIG1 ASGR1 ATP6V0C BET1 CD53 CERS2 CLEC17A CLEC7A EMP1 F8 FA2H FATE1 GLP1R GLUD1 HES1 HMOX2 IL1RL1 LAT LNPEP MCEMP1 MMD2 MROH5 MS4A13 NRG1 ORMDL1 PLN PLP2 PMP22 RPRM SEC22A SLC35A1 SLC35B2 SMIM3 SNCA STX8 TFRC TMEM140 TMEM60 TMEM86B TMPPE TRAM1L1 TSPO2 UBIAD1 UPK2 VAMP5 VKORC1 VTI1B YIPF1	12 interacting genes: AQP6 ASGR2 CD69 CLDN15 CREB3L1 CYB5R3 ERGIC3 LMNA SHISAL1 TEX29 TMEM237 TMEM248
Entrez ID		433	347734
HPRD ID		00152	11576
Ensembl ID		ENSG00000161944	ENSG00000157593
Uniprot IDs		P07307 Q7Z4G9	Q8TB61
PDB IDs		8URF	Not available
GO Terms Enriched among Interactors		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Protein Binding Regulation Of Mitotic Cell Cycle, Embryonic Pancreas Development Fucose Binding Regulation Of Secondary Heart Field Cardioblast Proliferation Endomembrane System Chloride Channel Inhibitor Activity Vesicle Fusion With Golgi Apparatus Plasma Membrane Pattern Recognition Receptor Activity Perinuclear Region Of Cytoplasm Regulation Of Calcium Ion Import Negative Regulation Of Gliogenesis Regulation Of Cardioblast Proliferation Bleb Assembly Positive Regulation Of Phosphate Metabolic Process SNARE Complex Organelle Membrane Identical Protein Binding Nephron Tubule Formation Negative Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Autophosphorylation Nephron Tubule Morphogenesis Cellular Response To Epinephrine Stimulus Vitamin K Metabolic Process Kidney Morphogenesis Positive Regulation Of Kinase Activity Negative Regulation Of Calcium Ion Import Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotactic Protein-1 Production	None