ASGR2 and CERS2

Number of citations of the paper that reports this interaction (PubMedID 11543633)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ASGR2	CERS2
Description		asialoglycoprotein receptor 2	ceramide synthase 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Fucose Binding	DNA Binding Protein Binding N-acyltransferase Activity Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Endocytosis Immune Response Cell Surface Receptor Signaling Pathway	Lipid Metabolic Process Sphingolipid Metabolic Process Negative Regulation Of Schwann Cell Proliferation Regulation Of Lipid Metabolic Process Sphingolipid Biosynthetic Process Response To Immobilization Stress Ceramide Biosynthetic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Migration Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration
Pathways		Asparagine N-linked glycosylation	Sphingolipid de novo biosynthesis
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Liver enzyme levels (alkaline phosphatase) ( 33972514) Total cholesterol levels ( 30275531)	Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Caffeine consumption from coffee or tea ( 33287642) Estimated glomerular filtration rate ( 31015462 31152163) Facial attractiveness (female raters) ( 30946739) Glycated hemoglobin levels ( 28898252 34059833) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Reticulocyte fraction of red cells ( 27863252) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		50 interacting genes: ADAM33 ADIPOQ AIG1 ASGR1 ATP6V0C BET1 CD53 CERS2 CLEC17A CLEC7A EMP1 F8 FA2H FATE1 GLP1R GLUD1 HES1 HMOX2 IL1RL1 LAT LNPEP MCEMP1 MMD2 MROH5 MS4A13 NRG1 ORMDL1 PLN PLP2 PMP22 RPRM SEC22A SLC35A1 SLC35B2 SMIM3 SNCA STX8 TFRC TMEM140 TMEM60 TMEM86B TMPPE TRAM1L1 TSPO2 UBIAD1 UPK2 VAMP5 VKORC1 VTI1B YIPF1	15 interacting genes: ASGR1 ASGR2 ATP6V0C CERS6 DRD2 HSP90AA1 IER3IP1 NFE2L2 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6 UBC YIF1A
Entrez ID		433	29956
HPRD ID		00152	06080
Ensembl ID		ENSG00000161944	ENSG00000143418
Uniprot IDs		P07307 Q7Z4G9	Q96G23
PDB IDs		8URF
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Protein Binding Regulation Of Mitotic Cell Cycle, Embryonic Pancreas Development Fucose Binding Regulation Of Secondary Heart Field Cardioblast Proliferation Endomembrane System Chloride Channel Inhibitor Activity Vesicle Fusion With Golgi Apparatus Plasma Membrane Pattern Recognition Receptor Activity Perinuclear Region Of Cytoplasm Regulation Of Calcium Ion Import Negative Regulation Of Gliogenesis Regulation Of Cardioblast Proliferation Bleb Assembly Positive Regulation Of Phosphate Metabolic Process SNARE Complex Organelle Membrane Identical Protein Binding Nephron Tubule Formation Negative Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Autophosphorylation Nephron Tubule Morphogenesis Cellular Response To Epinephrine Stimulus Vitamin K Metabolic Process Kidney Morphogenesis Positive Regulation Of Kinase Activity Negative Regulation Of Calcium Ion Import Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotactic Protein-1 Production	Negative Regulation Of Cellular Response To Hypoxia Asialoglycoprotein Receptor Activity Regulation Of Cellular Response To Hypoxia Transmembrane Transport Ubiquitin Protein Ligase Binding Thiamine Transmembrane Transporter Activity Thiamine Transport Thiamine Transmembrane Transport Membrane Fucose Binding Catecholamine Uptake Dopamine Uptake Protein Unfolding Azole Transmembrane Transport Plasma Membrane Pyrimidine-containing Compound Transmembrane Transport Negative Regulation Of Cytosolic Calcium Ion Concentration Vitamin Transmembrane Transport Dopamine Transport Neurotransmitter Reuptake D-mannose Binding Monoatomic Cation Transmembrane Transport Endoplasmic Reticulum Membrane Establishment Of Localization In Cell Monoamine Transport Neurotransmitter Uptake Organic Hydroxy Compound Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport COPII-coated ER To Golgi Transport Vesicle Pattern Recognition Receptor Activity Response To Cocaine Vitamin Transport CTP Binding DATP Binding Positive Regulation Of Glutathione Biosynthetic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Monoatomic Ion Transport Lateral Plasma Membrane G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Carboxylic Acid Transport Organic Acid Transport Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding
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