ASGR2 and VTI1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ASGR2	VTI1B
Description		asialoglycoprotein receptor 2	vesicle transport through interaction with t-SNAREs 1B
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Platelet Alpha Granule Lumen SNARE Complex Early Endosome Membrane Late Endosome Membrane Vesicle Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Presynaptic Endosome Membrane
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Fucose Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity
	Biological Process	Endocytosis Immune Response Cell Surface Receptor Signaling Pathway	Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Vesicle Docking Involved In Exocytosis Protein Transport Vesicle-mediated Transport Macroautophagy Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Membrane Fusion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane
Pathways		Asparagine N-linked glycosylation	Platelet degranulation
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Liver enzyme levels (alkaline phosphatase) ( 33972514) Total cholesterol levels ( 30275531)	Blood protein levels ( 30072576)
Interacting Genes		50 interacting genes: ADAM33 ADIPOQ AIG1 ASGR1 ATP6V0C BET1 CD53 CERS2 CLEC17A CLEC7A EMP1 F8 FA2H FATE1 GLP1R GLUD1 HES1 HMOX2 IL1RL1 LAT LNPEP MCEMP1 MMD2 MROH5 MS4A13 NRG1 ORMDL1 PLN PLP2 PMP22 RPRM SEC22A SLC35A1 SLC35B2 SMIM3 SNCA STX8 TFRC TMEM140 TMEM60 TMEM86B TMPPE TRAM1L1 TSPO2 UBIAD1 UPK2 VAMP5 VKORC1 VTI1B YIPF1	38 interacting genes: AQP6 ASGR2 BIK CD46 CD79A CFTR CRB3 CREB3 ERGIC3 FCGR1A GOLGB1 GPR35 GPX8 JAGN1 KASH5 KLRC1 KRTAP10-7 LDLRAD1 LMNA MANBAL PTPN5 REEP4 RNASEK SAR1A SLC16A7 SLC18A1 SLC35H1 STX1A STX2 STX4 STX7 STX8 SYNE4 TMEM14B TMEM234 TMEM51 TNK2 TRIM59
Entrez ID		433	10490
HPRD ID		00152	04440
Ensembl ID		ENSG00000161944	ENSG00000100568
Uniprot IDs		P07307 Q7Z4G9	Q9UEU0
PDB IDs		8URF	2V8S
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Protein Binding Regulation Of Mitotic Cell Cycle, Embryonic Pancreas Development Fucose Binding Regulation Of Secondary Heart Field Cardioblast Proliferation Endomembrane System Chloride Channel Inhibitor Activity Vesicle Fusion With Golgi Apparatus Plasma Membrane Pattern Recognition Receptor Activity Perinuclear Region Of Cytoplasm Regulation Of Calcium Ion Import Negative Regulation Of Gliogenesis Regulation Of Cardioblast Proliferation Bleb Assembly Positive Regulation Of Phosphate Metabolic Process SNARE Complex Organelle Membrane Identical Protein Binding Nephron Tubule Formation Negative Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Autophosphorylation Nephron Tubule Morphogenesis Cellular Response To Epinephrine Stimulus Vitamin K Metabolic Process Kidney Morphogenesis Positive Regulation Of Kinase Activity Negative Regulation Of Calcium Ion Import Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotactic Protein-1 Production	Membrane Chloride Channel Inhibitor Activity Vesicle Docking Organelle Localization By Membrane Tethering SNAP Receptor Activity Membrane Docking SNARE Complex SNARE Binding Vesicle-mediated Transport Endomembrane System Vesicle Fusion Organelle Membrane Fusion Organelle Localization Membrane Organization Organelle Fusion Membrane Fusion Vesicle Organization Cornified Envelope Assembly Intracellular Protein Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Membrane Assembly Positive Regulation Of Immune Effector Process SNARE Complex Assembly Endoplasmic Reticulum Membrane Regulation Of Insulin Secretion Regulation Of Protein Localization Regulation Of Peptide Hormone Secretion Regulation Of Cellular Localization Positive Regulation Of Exocytosis Exocytosis Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Lymphocyte Mediated Immunity Nuclear Envelope Organization Protein Binding Water Transport Endoplasmic Reticulum Regulation Of Adaptive Immune Response Neurotransmitter Transport Schaffer Collateral - CA1 Synapse Establishment Of Localization In Cell Nitrate Transmembrane Transporter Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Basolateral Plasma Membrane Protein Transport Presynaptic Active Zone Membrane High-affinity IgG Receptor Activity Inhibitory MHC Class Ib Receptor Activity
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