ASGR2 and CLEC17A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ASGR2	CLEC17A
Description		asialoglycoprotein receptor 2	C-type lectin domain containing 17A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm	External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Fucose Binding	Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Identical Protein Binding Fucose Binding Metal Ion Binding
	Biological Process	Endocytosis Immune Response Cell Surface Receptor Signaling Pathway	Immune Response
Pathways		Asparagine N-linked glycosylation
Drugs		Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Liver enzyme levels (alkaline phosphatase) ( 33972514) Total cholesterol levels ( 30275531)	Femur bone mineral density x serum urate levels interaction ( 34046847) Iris color (L* coordinate) ( 30895295) Low density lipoprotein cholesterol levels ( 33339817) Response to antidepressants (symptom improvement) ( 29160301) Total cholesterol levels ( 33339817)
Interacting Genes		50 interacting genes: ADAM33 ADIPOQ AIG1 ASGR1 ATP6V0C BET1 CD53 CERS2 CLEC17A CLEC7A EMP1 F8 FA2H FATE1 GLP1R GLUD1 HES1 HMOX2 IL1RL1 LAT LNPEP MCEMP1 MMD2 MROH5 MS4A13 NRG1 ORMDL1 PLN PLP2 PMP22 RPRM SEC22A SLC35A1 SLC35B2 SMIM3 SNCA STX8 TFRC TMEM140 TMEM60 TMEM86B TMPPE TRAM1L1 TSPO2 UBIAD1 UPK2 VAMP5 VKORC1 VTI1B YIPF1	21 interacting genes: ASGR2 ATP6V0C CLDN8 CTXN3 CXCL9 FAM3C GPR152 IGFBP5 NCK2 NINJ2 OLFM4 PELI1 PELI2 RPRM SEC23A SMIM3 TM4SF4 TMEM140 TMEM201 TMEM218 UPK2
Entrez ID		433	388512
HPRD ID		00152	16993
Ensembl ID		ENSG00000161944	ENSG00000187912
Uniprot IDs		P07307 Q7Z4G9	Q6ZS10
PDB IDs		8URF
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Protein Binding Regulation Of Mitotic Cell Cycle, Embryonic Pancreas Development Fucose Binding Regulation Of Secondary Heart Field Cardioblast Proliferation Endomembrane System Chloride Channel Inhibitor Activity Vesicle Fusion With Golgi Apparatus Plasma Membrane Pattern Recognition Receptor Activity Perinuclear Region Of Cytoplasm Regulation Of Calcium Ion Import Negative Regulation Of Gliogenesis Regulation Of Cardioblast Proliferation Bleb Assembly Positive Regulation Of Phosphate Metabolic Process SNARE Complex Organelle Membrane Identical Protein Binding Nephron Tubule Formation Negative Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Autophosphorylation Nephron Tubule Morphogenesis Cellular Response To Epinephrine Stimulus Vitamin K Metabolic Process Kidney Morphogenesis Positive Regulation Of Kinase Activity Negative Regulation Of Calcium Ion Import Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Monocyte Chemotactic Protein-1 Production	Regulation Of Toll Signaling Pathway
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