CYBC1 and P2RX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYBC1	P2RX1
Description		cytochrome b-245 chaperone 1	purinergic receptor P2X 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane Protein-containing Complex Specific Granule Membrane Membrane Raft Postsynaptic Membrane Presynaptic Active Zone Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding ATP Binding Channel Activity Identical Protein Binding Suramin Binding Protein-containing Complex Binding Ligand-gated Calcium Channel Activity
	Biological Process	Immune System Process Innate Immune Response Respiratory Burst After Phagocytosis	Serotonin Secretion By Platelet Regulation Of Vascular Associated Smooth Muscle Contraction Monoatomic Ion Transport Apoptotic Process Regulation Of Smooth Muscle Contraction Signal Transduction Insemination Regulation Of Blood Pressure Neuronal Action Potential Regulation Of Vasoconstriction Calcium-mediated Signaling Platelet Activation Response To ATP Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Monoatomic Ion Transport Ceramide Biosynthetic Process Establishment Of Localization In Cell Regulation Of Calcium Ion Transport Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Synaptic Vesicle Exocytosis
Pathways			Elevation of cytosolic Ca2+ levels Platelet homeostasis Neutrophil degranulation
Drugs			Promethazine
Diseases
GWAS			Mean platelet volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		65 interacting genes: ADIPOQ AGTRAP AHNAK2 AIG1 APCDD1L APOA2 APOL2 AQP10 AQP6 AQP8 ARLN BET1 C14orf180 CD53 CISD2 CLDN7 CLN6 COQ9 CPLX4 CREB3 CREB3L1 CYBB ERGIC3 ETS1 FAM209A GJA8 GPR151 GPR152 GPX8 HSD17B11 HSD17B13 INSIG2 JAGN1 KASH5 KIR2DL3 LAT LMNA LXN MFF MGST3 MTIF3 NINJ2 NOX3 NRM P2RX1 PDZK1IP1 PEX12 PLIN3 PLP1 PLP2 SCD SHISA4 SLC35H1 SLC71A2 SPN SSMEM1 STX2 THBD TM4SF19 TMEM128 TMEM80 TMPRSS2 TMX2 TRAM1L1 TSPAN12	2 interacting genes: CYBC1 P2RX2
Entrez ID		79415	5023
HPRD ID		14630	07526
Ensembl ID		ENSG00000178927	ENSG00000108405
Uniprot IDs		Q9BQA9	P51575
PDB IDs		8KEI	9B73 9B95 9C2A 9C2B 9C2C
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Endoplasmic Reticulum Membrane Endoplasmic Reticulum Water Channel Activity Channel Activity Negative Regulation Of Cholesterol Import Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Oxygen As Acceptor Regulation Of Cholesterol Import One-carbon Compound Transport Water Transport Superoxide-generating NADPH Oxidase Activity Identical Protein Binding Fluid Transport Lipid Droplet Ammonium Channel Activity Urea Transmembrane Transport	Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Urinary Bladder Smooth Muscle Contraction Purinergic Nucleotide Receptor Activity Peristalsis Extracellularly ATP-gated Monoatomic Cation Channel Activity Respiratory Burst Involved In Defense Response Respiratory Burst After Phagocytosis Positive Regulation Of Calcium Ion Transport Into Cytosol Purinergic Nucleotide Receptor Signaling Pathway Neuronal Dense Core Vesicle Regulation Of Calcium Ion Transport Into Cytosol Behavioral Response To Pain Respiratory Burst Skeletal Muscle Fiber Development Sensory Perception Of Taste Ligand-gated Monoatomic Ion Channel Activity Response To ATP Neuromuscular Synaptic Transmission Myotube Cell Development Neuromuscular Junction Development Smooth Muscle Contraction Positive Regulation Of Calcium-mediated Signaling Excitatory Postsynaptic Potential Response To Ischemia Positive Regulation Of Calcium Ion Transmembrane Transport Striated Muscle Cell Development
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