SERPINF2 and F13A1

Number of citations of the paper that reports this interaction (PMID 10958788)
5

Data Source:
HPRD (in vitro)

		SERPINF2	F13A1
Gene Name		serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	coagulation factor XIII, A1 polypeptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Platelet Alpha Granule Lumen Blood Microparticle
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity	Protein-glutamine Gamma-glutamyltransferase Activity Metal Ion Binding
	Biological Process	Regulation Of Blood Vessel Size By Renin-angiotensin Platelet Degranulation Acute-phase Response Blood Coagulation Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Platelet Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Platelet Degranulation Blood Coagulation Peptide Cross-linking Platelet Activation
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation	Common Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
Drugs		Ocriplasmin	1,2-Propanediol N-Acetyl-Serine
Diseases
GWAS		Calcium levels ( 20705733) Serum albumin level ( 23022100)	End-stage coagulation ( 23381943) MRI atrophy measures ( 21116278)
Protein-Protein Interactions		17 interactors: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	13 interactors: ANXA7 CDKN1A F13B F2 FGA FGG FN1 NUDT21 PTK2 SERPINF2 SH3GL2 TK1 UFD1L
Entrez ID		5345	2162
HPRD ID		02029	00604
Ensembl ID		ENSG00000167711	ENSG00000124491
Uniprot IDs		P08697	P00488
PDB IDs			1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Wound Healing Negative Regulation Of Wound Healing Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Response To Wounding Blood Coagulation Hemostasis Protein Metabolic Process Regulation Of Blood Coagulation Regulation Of Wound Healing Regulation Of Body Fluid Levels Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Stress Vesicle-mediated Transport Regulation Of Fibrinolysis Mitochondrial Calcium Ion Homeostasis Cobalamin Metabolic Process Exocytosis Killing Of Cells Of Other Organism Defense Response To Fungus Fibrinolysis Protein Activation Cascade Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell-substrate Adhesion Response To Fungus Secretion By Cell Immune System Process Peptide Cross-linking Protein Processing Tissue Regeneration Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Regulation Of Cell Adhesion Secretion Collagen Catabolic Process Cellular Calcium Ion Homeostasis Cell Activation Calcium Ion Homeostasis Cellular Homeostasis Positive Regulation Of Signal Transduction Collagen Metabolic Process	Hemostasis Regulation Of Body Fluid Levels Platelet Activation Blood Coagulation Wound Healing Response To Wounding Platelet Degranulation Regulation Of Cell Morphogenesis Regulation Of Cellular Component Organization Cell Activation Extracellular Matrix Organization Extracellular Structure Organization Acute-phase Response Regulation Of Cell Shape Positive Regulation Of Phosphorylation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Protein Complex Assembly Acute Inflammatory Response Negative Regulation Of Fibrinolysis Response To Stress Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Blood Coagulation Regulation Of Fibrinolysis Response To Metal Ion Exocytosis Response To Calcium Ion Regulation Of Phosphorylation Regulation Of Cell-cell Adhesion Defense Response Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Wound Healing Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Negative Regulation Of Endothelial Cell Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Collagen Biosynthetic Process Regulation Of Cell Differentiation ERBB Signaling Pathway Positive Regulation Of Collagen Metabolic Process Response To Inorganic Substance Cell-matrix Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fibrinolysis Secretion By Cell
Tagcloud ?			10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vim vws woude z
Tagcloud (Difference) ?			10p13 17q21 5q15 6p24 australian british cl cleft crtl1 d1s58 d1s65 der excluded flank inheritance linkage lip lod multipoint palate rara syndromic theta unrelated van vim vws woude z
Tagcloud (Intersection) ?