SERPINF2 and KLK13

Number of citations of the paper that reports this interaction (PubMedID 14687906)
0

Data Source:
HPRD (in vitro)

		SERPINF2	KLK13
Description		serpin family F member 2	kallikrein related peptidase 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Cytoplasm Secretory Granule
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Protein Homodimerization Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Acute-phase Response Negative Regulation Of Plasminogen Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Proteolysis Protein Processing Protein Maturation
Pathways		Platelet degranulation Dissolution of Fibrin Clot	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Formation of the cornified envelope
Drugs		Ocriplasmin Copper
Diseases		Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS		Calcium levels ( 20705733 24068962) Hodgkin's lymphoma ( 34216518) Serum albumin levels ( 23022100 29403010) Severe insulin-deficient type 2 diabetes ( 34737425) Urate levels ( 31578528)	Blood protein levels ( 30072576)
Interacting Genes		17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	3 interacting genes: A2M SERPINA3 SERPINF2
Entrez ID		5345	26085
HPRD ID		02029	05693
Ensembl ID		ENSG00000167711	ENSG00000167759
Uniprot IDs		P08697	M0R218 Q5BQ99 Q86VI7 Q9UKR3
PDB IDs
Enriched GO Terms of Interacting Partners?		Serine-type Peptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Protein Processing Protein Maturation Extracellular Space Proteolysis Extracellular Region Zymogen Activation Blood Coagulation Coagulation Hydrolase Activity Hemostasis Extracellular Matrix Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protein Metabolic Process Platelet Alpha Granule Lumen Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Fibrinolysis Secretory Granule Positive Regulation Of Fibrinolysis Blood Microparticle Biological Process Involved In Interaction With Symbiont Regulation Of Body Fluid Levels Extracellular Exosome Regulation Of Wound Healing Extracellular Matrix Disassembly Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Response To Wounding Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Fibrinolysis Endopeptidase Activity Macromolecule Metabolic Process Peptide Cross-linking Protein Activation Cascade Negative Regulation Of Protein Maturation Positive Regulation Of Blood Coagulation Digestion Cell Surface Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Response To Bacterium Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Serine-type Aminopeptidase Activity	Platelet Alpha Granule Lumen Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Blood Microparticle Acute-phase Response Endopeptidase Inhibitor Activity Extracellular Matrix Acute Inflammatory Response Protease Binding Negative Regulation Of Complement Activation, Lectin Pathway Interleukin-8 Binding Lactose Synthase Activity N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Tumor Necrosis Factor Binding Interleukin-1 Binding Negative Regulation Of Plasminogen Activation Galactosyltransferase Activity Fibrinogen Complex Extracellular Space System Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Cerebellar Purkinje Cell Layer Development Negative Regulation Of Fibrinolysis Negative Regulation Of Complement Activation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Complement Activation Maintenance Of Gastrointestinal Epithelium Inflammatory Response Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Blood Coagulation Fibrinolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Positive Regulation Of Collagen Biosynthetic Process Extracellular Exosome Extracellular Region Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Coagulation Epithelial Structure Maintenance Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Systemic Arterial Blood Pressure Growth Factor Binding Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?