SERPINF2 and DEFA1

Number of citations: 0 (PubMedID 7873202)
Data Source: HPRD (in vitro)

		SERPINF2	DEFA1
Name		serpin family F member 2	defensin alpha 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Protein Homodimerization Activity	Protein Binding Pore-forming Activity
	Biological Process	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Acute-phase Response Negative Regulation Of Plasminogen Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Innate Immune Response In Mucosa Chemotaxis Defense Response Immune Response T Cell Chemotaxis Antibacterial Humoral Response Estrogen Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Disruption Of Plasma Membrane Integrity In Another Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Platelet degranulation Dissolution of Fibrin Clot	Defensins Alpha-defensins Neutrophil degranulation
Drugs		Ocriplasmin Copper	None
Diseases		Alpha-2-plasmin inhibitor (a2-PI) deficiency	None
GWAS		Calcium levels ( 20705733 24068962 ) Hodgkin's lymphoma ( 34216518 ) Serum albumin levels ( 23022100 29403010 ) Severe insulin-deficient type 2 diabetes ( 34737425 ) Urate levels ( 31578528 )	Basophil percentage of white cells ( 32888494 ) Blood protein levels ( 30072576 ) Chromium levels ( 26025379 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Endometriosis ( 28333195 ) Periodontitis (PAL4Q3) ( 24024966 )
Novel Interactors		1 novel interactors: MYH10	None recorded
Interacting Genes		17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	7 interacting genes: ACE2 C1QB DEFA3 GSK3B PFDN1 SERPINF2 UBQLN2
Entrez ID		5345	1667
HPRD ID		02029	00499
Ensembl ID		ENSG00000167711	ENSG00000206047
Uniprot IDs		P08697	P59665
PDB IDs		Not available	2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0 4LB1 4LB7 4LBB 4LBF
GO Terms Enriched among Interactors		Serine-type Peptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Protein Processing Protein Maturation Extracellular Space Proteolysis Extracellular Region Zymogen Activation Blood Coagulation Coagulation Hydrolase Activity Hemostasis Extracellular Matrix Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protein Metabolic Process Platelet Alpha Granule Lumen Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Fibrinolysis Secretory Granule Positive Regulation Of Fibrinolysis Blood Microparticle Biological Process Involved In Interaction With Symbiont Regulation Of Body Fluid Levels Extracellular Exosome Regulation Of Wound Healing Extracellular Matrix Disassembly Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Response To Wounding Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Fibrinolysis Endopeptidase Activity Macromolecule Metabolic Process Peptide Cross-linking Protein Activation Cascade Negative Regulation Of Protein Maturation Positive Regulation Of Blood Coagulation Digestion Cell Surface Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Response To Bacterium Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Serine-type Aminopeptidase Activity	Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Systemic Arterial Blood Pressure Complement Component C1q Complex IgM Binding Complement Component C1 Complex Cell Surface Blood Microparticle Disruption Of Plasma Membrane Integrity In Another Organism Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Superior Temporal Gyrus Development Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Proteolysis Regulation Of Protein Metabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of TORC2 Signaling Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Dopaminergic Neuron Differentiation Protease Binding Regulation Of Glycogen (starch) Synthase Activity Viral Process Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance Regulation Of Blood Pressure Regulation Of Tube Size Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Viral Translation Viral Life Cycle Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Tryptophan Transport Entry Receptor-mediated Virion Attachment To Host Cell Peptidyl-dipeptidase Activity Negative Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization To Cilium Positive Regulation Of Gap Junction Assembly Pore-forming Activity Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Interleukin-3 Positive Regulation Of Protein Localization To Centrosome