SERPINF2 and SSR1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SERPINF2	SSR1
Name		serpin family F member 2	signal sequence receptor subunit 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Protein Homodimerization Activity	Protein Binding
	Biological Process	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Acute-phase Response Negative Regulation Of Plasminogen Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Population Proliferation
Pathways		Platelet degranulation Dissolution of Fibrin Clot	SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes
Drugs		Ocriplasmin Copper	None
Diseases		Alpha-2-plasmin inhibitor (a2-PI) deficiency	None
GWAS		Calcium levels ( 20705733 24068962 ) Hodgkin's lymphoma ( 34216518 ) Serum albumin levels ( 23022100 29403010 ) Severe insulin-deficient type 2 diabetes ( 34737425 ) Urate levels ( 31578528 )	Brain morphology (MOSTest) ( 32665545 ) Ewing sarcoma ( 30093639 ) Hip circumference adjusted for BMI ( 34021172 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Subcortical volume (MOSTest) ( 32665545 ) Type 2 diabetes ( 24509480 28869590 30718926 32499647 )
Novel Interactors		1 novel interactors: MYH10	1 novel interactors: NPC2
Interacting Genes		17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	8 interacting genes: DKC1 EEF1A1 HSPA13 NUP54 ODC1 PTN SERPINF2 UTP14A
Entrez ID		5345	6745
HPRD ID		02029	02924
Ensembl ID		ENSG00000167711	ENSG00000124783
Uniprot IDs		P08697	C9JBX5 P43307
PDB IDs		Not available	8B6L
GO Terms Enriched among Interactors		Serine-type Peptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Protein Processing Protein Maturation Extracellular Space Proteolysis Extracellular Region Zymogen Activation Blood Coagulation Coagulation Hydrolase Activity Hemostasis Extracellular Matrix Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protein Metabolic Process Platelet Alpha Granule Lumen Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Fibrinolysis Secretory Granule Positive Regulation Of Fibrinolysis Blood Microparticle Biological Process Involved In Interaction With Symbiont Regulation Of Body Fluid Levels Extracellular Exosome Regulation Of Wound Healing Extracellular Matrix Disassembly Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Response To Wounding Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Fibrinolysis Endopeptidase Activity Macromolecule Metabolic Process Peptide Cross-linking Protein Activation Cascade Negative Regulation Of Protein Maturation Positive Regulation Of Blood Coagulation Digestion Cell Surface Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Response To Bacterium Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Serine-type Aminopeptidase Activity	None