PLD2 and ARF1

Number of citations of the paper that reports this interaction (PubMedID 10801846)
0

Data Source:
HPRD (in vivo)

		PLD2	ARF1
Description		phospholipase D2	ARF GTPase 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cytoplasmic Vesicle Brush Border Membrane Presynapse	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endomembrane System Postsynaptic Density Membrane Sarcomere Cell Leading Edge Protein-containing Complex Neuron Projection Synapse Extracellular Exosome
	Molecular Function	Catalytic Activity Phospholipase D Activity Protein Binding Hydrolase Activity Phosphatidylinositol Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding
	Biological Process	G Protein-coupled Receptor Internalization Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Receptor-mediated Endocytosis Cytoskeleton Organization Small GTPase-mediated Signal Transduction Phospholipid Catabolic Process Lipid Catabolic Process Intracellular Signal Transduction Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vesicle-mediated Transport	Regulation Of Receptor Internalization Intracellular Copper Ion Homeostasis Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Long-term Synaptic Depression Dendritic Spine Organization Cellular Response To Virus Mitotic Cleavage Furrow Ingression
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis RAC1 GTPase cycle RAC2 GTPase cycle	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Glycosphingolipid transport
Drugs		Choline Choline salicylate	1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Chlortetracycline Glycerin
Diseases
GWAS		Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)	Adolescent idiopathic scoliosis ( 31417091)
Interacting Genes		29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL	50 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DENND1A DENND1B DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 SNCA TMED10 TMED2 TMEM106A WBP11
Entrez ID		5338	375
HPRD ID		03857	00054
Ensembl ID		ENSG00000129219	ENSG00000143761
Uniprot IDs		O14939	P84077
PDB IDs		6OHM 6OHO 6OHP 6OHQ 6OHS 7SVP	1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE 7DN8 7DN9 7MGE 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9U 8D9W 8SDW 9C58 9C59 9C5A 9C5B
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process T Cell Costimulation Protein Tyrosine Kinase Activity Phospholipase Activator Activity Positive Regulation Of Immune System Process Cytosol Negative Regulation Of Apoptotic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Phospholipase Binding Cell-cell Junction Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Glycolytic Process Plasma Membrane Regulation Of Transport Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Regulation Of Multicellular Organismal Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of T Cell Activation Cytoplasm Cellular Response To Oxygen Levels Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Cellular Response To Chemical Stress Fc-gamma Receptor Signaling Pathway Identical Protein Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of ATP Metabolic Process Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Cell Development Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Peptide Hormone Protein Kinase Binding Regulation Of Cell Activation Positive Regulation Of Developmental Process Regulation Of Biological Quality	Vesicle-mediated Transport Intracellular Protein Localization Golgi Apparatus Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Establishment Of Localization In Cell Golgi Vesicle Transport Intracellular Protein Transport Membrane Coat Golgi Membrane Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Trans-Golgi Network Membrane Melanosome Assembly Localization Within Membrane Platelet Dense Granule Organization Post-Golgi Vesicle-mediated Transport Vesicle Cargo Loading COPI Vesicle Coat COPI-coated Vesicle Melanosome Organization Pigment Granule Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Localization To Membrane Golgi To Vacuole Transport Early Endosome Transport Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Trans-Golgi Network Secretory Granule Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Cell Surface Intra-Golgi Vesicle-mediated Transport Organelle Organization Vesicle Organization Clathrin-coated Vesicle Membrane Synaptic Vesicle Transport Vesicle Coating AP-3 Adaptor Complex Protein Localization To Cell Periphery Endocytosis Clathrin Adaptor Complex Organelle Transport Along Microtubule Cytosol Synaptic Vesicle Budding From Endosome Vacuolar Transport
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