PLD2 and ALDOC

Number of citations of the paper that reports this interaction (PubMedID 11876650)
0

Data Source:
HPRD (in vitro)

		PLD2	ALDOC
Description		phospholipase D2	aldolase, fructose-bisphosphate C
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cytoplasmic Vesicle Brush Border Membrane Presynapse	Extracellular Region Cytosol Cytoskeleton Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Catalytic Activity Phospholipase D Activity Protein Binding Hydrolase Activity Phosphatidylinositol Binding	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Lyase Activity
	Biological Process	G Protein-coupled Receptor Internalization Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Receptor-mediated Endocytosis Cytoskeleton Organization Small GTPase-mediated Signal Transduction Phospholipid Catabolic Process Lipid Catabolic Process Intracellular Signal Transduction Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vesicle-mediated Transport	Fructose Metabolic Process Gluconeogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Epithelial Cell Differentiation
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis RAC1 GTPase cycle RAC2 GTPase cycle	Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs		Choline Choline salicylate
Diseases
GWAS		Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)
Interacting Genes		29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL	9 interacting genes: ANKS1A ATP6V1E1 CFTR ERBB2 FMR1 LNX1 MAP2K3 PLD2 SQLE
Entrez ID		5338	230
HPRD ID		03857	02386
Ensembl ID		ENSG00000129219	ENSG00000109107
Uniprot IDs		O14939	A0A024QZ64 P09972
PDB IDs		6OHM 6OHO 6OHP 6OHQ 6OHS 7SVP	1XFB
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process T Cell Costimulation Protein Tyrosine Kinase Activity Phospholipase Activator Activity Positive Regulation Of Immune System Process Cytosol Negative Regulation Of Apoptotic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Phospholipase Binding Cell-cell Junction Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Glycolytic Process Plasma Membrane Regulation Of Transport Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Regulation Of Multicellular Organismal Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of T Cell Activation Cytoplasm Cellular Response To Oxygen Levels Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Cellular Response To Chemical Stress Fc-gamma Receptor Signaling Pathway Identical Protein Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of ATP Metabolic Process Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Cell Development Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Peptide Hormone Protein Kinase Binding Regulation Of Cell Activation Positive Regulation Of Developmental Process Regulation Of Biological Quality	Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex, Catalytic Domain Cholesterol Biosynthetic Process Regulation Of Transmembrane Transporter Activity Developmental Maturation Positive Regulation Of Anion Channel Activity Steroid Biosynthetic Process Sterol Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding PDZ Domain Binding Regulation Of Monoatomic Ion Transmembrane Transporter Activity ERBB3:ERBB2 Complex Dendritic Filopodium Histone H3 Reader Activity Positive Regulation Of Intracellular Transport Of Viral Material Cellular Response To Sorbitol Squalene Monooxygenase Activity Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Hepatoblast Differentiation Regulation Of Pronephros Size Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Positive Regulation Of Monoatomic Anion Transport RNA Polymerase I Core Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Long-term Synaptic Depression Growth Cone Filopodium Response To Biphenyl Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Proton-transporting Two-sector ATPase Complex Sterol Metabolic Process Cholesterol Metabolic Process Positive Regulation Of Tooth Mineralization Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Lipid Biosynthetic Process Cell Maturation Regulation Of Vesicle-mediated Transport Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Negative Regulation Of Immature T Cell Proliferation ErbB-3 Class Receptor Binding Presynaptic Membrane
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