PLD2 and ALDOA

Number of citations of the paper that reports this interaction (PubMedID 11876650)
0

Data Source:
HPRD (in vivo, in vitro)

		PLD2	ALDOA
Description		phospholipase D2	aldolase, fructose-bisphosphate A
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cytoplasmic Vesicle Brush Border Membrane Presynapse	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Actin Cytoskeleton Membrane Platelet Alpha Granule Lumen M Band I Band Secretory Granule Lumen Sperm Head Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Catalytic Activity Phospholipase D Activity Protein Binding Hydrolase Activity Phosphatidylinositol Binding	RNA Binding Actin Binding Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Tubulin Binding Lyase Activity Identical Protein Binding Cadherin Binding Fructose Binding
	Biological Process	G Protein-coupled Receptor Internalization Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Receptor-mediated Endocytosis Cytoskeleton Organization Small GTPase-mediated Signal Transduction Phospholipid Catabolic Process Lipid Catabolic Process Intracellular Signal Transduction Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vesicle-mediated Transport	Fructose Metabolic Process Glycolytic Process ATP Biosynthetic Process Striated Muscle Contraction Actin Filament Organization Binding Of Sperm To Zona Pellucida Regulation Of Cell Shape Fructose 1,6-bisphosphate Metabolic Process Muscle Cell Cellular Homeostasis Protein Homotetramerization
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis RAC1 GTPase cycle RAC2 GTPase cycle	Platelet degranulation Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs		Choline Choline salicylate	Zinc 1,6-Fructose Diphosphate (Linear Form) Dihydroxyacetone phosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL	37 interacting genes: ADRB2 ATP6V1E1 BCAT2 CACNA1A CEBPA CYTH2 DSCR9 DYNLL1 ENO1 ENO3 ERBB2 ERBB3 ERBB4 FANCA GALNT6 GPD2 HSD17B10 HSPB2 IFNA4 LCOR LINC01554 MLH1 MYOC NXF1 OGT PCNA PIAS4 PLD2 SHANK3 SLC22A1 SRPK2 SUMO4 TERF1 TGM2 TRIM63 TUBB XRN1
Entrez ID		5338	226
HPRD ID		03857	00070
Ensembl ID		ENSG00000129219	ENSG00000149925
Uniprot IDs		O14939	P04075 V9HWN7
PDB IDs		6OHM 6OHO 6OHP 6OHQ 6OHS 7SVP	1ALD 2ALD 4ALD 5KY6 6XMH 6XML 6XMM 6XMO
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process T Cell Costimulation Protein Tyrosine Kinase Activity Phospholipase Activator Activity Positive Regulation Of Immune System Process Cytosol Negative Regulation Of Apoptotic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Phospholipase Binding Cell-cell Junction Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Glycolytic Process Plasma Membrane Regulation Of Transport Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Regulation Of Multicellular Organismal Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of T Cell Activation Cytoplasm Cellular Response To Oxygen Levels Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Cellular Response To Chemical Stress Fc-gamma Receptor Signaling Pathway Identical Protein Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of ATP Metabolic Process Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Cell Development Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Peptide Hormone Protein Kinase Binding Regulation Of Cell Activation Positive Regulation Of Developmental Process Regulation Of Biological Quality	ERBB2 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB3:ERBB2 Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Basal Plasma Membrane Neuregulin Receptor Activity Negative Regulation Of DNA Metabolic Process ERBB Signaling Pathway Isoleucine Metabolic Process L-isoleucine Catabolic Process ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Adaptation Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation ERBB4 Signaling Pathway Telomere Localization Gluconeogenesis Hexose Biosynthetic Process Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Response To Stress Regulation Of Small GTPase Mediated Signal Transduction Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of DNA Metabolic Process Receptor Complex Regulation Of Purine Nucleotide Metabolic Process Canonical Glycolysis Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of DNA Biosynthetic Process Dopamine Transport Brown Fat Cell Differentiation Positive Regulation Of Excitatory Postsynaptic Potential Import Into Cell Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Protein-containing Complex Binding Positive Regulation Of Mini Excitatory Postsynaptic Potential Branched-chain Amino Acid Metabolic Process Branched-chain Amino Acid Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glycolytic Process Through Glucose-6-phosphate M Band Nicotinamide Nucleotide Metabolic Process
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