PLD2 and AQP3

Number of citations of the paper that reports this interaction (PMID 14675200)
16

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		PLD2	AQP3
Gene Name		phospholipase D2	aquaporin 3 (Gill blood group)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Brush Border Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Transporter Activity Urea Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity
	Biological Process	G-protein Coupled Receptor Internalization Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Glycerophospholipid Biosynthetic Process	Positive Regulation Of Immune System Process Renal Water Homeostasis Transport Water Transport Excretion Cellular Water Homeostasis Glycerol Transport Response To Retinoic Acid Response To Vitamin D Carbohydrate Transmembrane Transport Ion Transmembrane Transport Odontogenesis Regulation Of Keratinocyte Differentiation Response To Calcium Ion Transmembrane Transport Renal Water Absorption Urea Transmembrane Transport
Pathways		Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Aquaporin-mediated transport
Drugs
Diseases
GWAS		Sphingolipid levels ( 22359512)
Protein-Protein Interactions		26 interactors: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A LCK MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1	1 interactors: PLD2
Entrez ID		5338	360
HPRD ID		03857	08970
Ensembl ID		ENSG00000129219	ENSG00000165272
Uniprot IDs		I3L2C9 O14939	Q92482
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Epidermal Growth Factor Receptor Signaling Pathway Response To Wounding ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Stress Response To Organic Substance Endocytosis Cell Activation Vesicle-mediated Transport Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To External Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process T Cell Costimulation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Response To Organonitrogen Compound Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Protein Autophosphorylation Immune Response Regulation Of Cellular Localization Regulation Of Cell-cell Adhesion Defense Response Regulation Of Intracellular Signal Transduction Response To Growth Factor Immune System Process Regulation Of Signaling Positive Regulation Of Phosphorylation Negative Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Transport Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Cellular Response To Organonitrogen Compound Regulation Of Cell Activation	G-protein Coupled Receptor Internalization Phosphatidylglycerol Biosynthetic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Synaptic Vesicle Recycling Receptor Internalization Receptor Metabolic Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Synaptic Vesicle Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Glycerophospholipid Biosynthetic Process Establishment Of Vesicle Localization Vesicle Localization Phospholipid Biosynthetic Process Lipid Catabolic Process Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Glycerophospholipid Metabolic Process Establishment Of Organelle Localization Receptor-mediated Endocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Glycerolipid Metabolic Process Phospholipid Metabolic Process Organelle Localization Immune Response-regulating Signaling Pathway
Tagcloud ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld1 responsive se secretion tumorigenesis u87 utilize vegf	aquaporin caveolin cay10594 controversy d2 dead differentiation differentiative elevation epidermal funnels glycerol hypothesized idea keratin keratinocyte keratinocytes knockout ld lipase loricrin microdomains phospholipase pld1 pld2 pro re require transports
Tagcloud (Difference) ?		1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine responsive se secretion tumorigenesis u87 utilize vegf	aquaporin caveolin cay10594 controversy d2 dead differentiation differentiative elevation epidermal funnels glycerol hypothesized idea keratin keratinocyte keratinocytes knockout ld lipase loricrin microdomains pro re require transports
Tagcloud (Intersection) ?		phospholipase pld1 pld2