NUP54 and ZWINT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NUP54	ZWINT
Description		nucleoporin 54	ZW10 interacting kinetochore protein
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Membrane Nuclear Membrane Nuclear Pore Central Transport Channel	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body Dendrite Knl1/Spc105 Complex
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore	Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport Protein Localization To Nuclear Inner Membrane MRNA Transport	Mitotic Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Homologous Chromosome Orientation In Meiotic Metaphase I Cell Division Establishment Of Localization In Cell Regulation Of Meiosis I Spindle Assembly Checkpoint
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Hippocampal volume ( 29274321)	Cardiac hypertrophy ( 21348951) Cognitive function in longevity ( 33607172) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Liver fibrosis (total hepatic collagen content) ( 32953199)
Interacting Genes		46 interacting genes: AGR2 AIRIM AP1B1 AP2B1 APC BPIFA1 C14orf119 C21orf91 CCDC85B CCHCR1 CDC23 CENPH DCTN3 DGCR6 EFHC1 EIF3F EXOC1 EXOC8 HAUS1 HAUS8 HGS IFT20 KPNA1 KPNB1 KRT15 KRT27 KRT33B NFKBID NR3C1 NUP62 NUTF2 OGT OIP5 PKNOX2 SMYD3 SOHLH1 SPG21 SSR1 TACC3 TCHP TEKT1 TEX12 TPM3 TRIM54 VPS37C ZWINT	17 interacting genes: APP BCAS2 BFSP1 CCHCR1 CLU DSN1 FAM90A1 KRT75 LIG4 MAFB MIS12 MSGN1 NDC80 NUP54 PHAX TSG101 ZW10
Entrez ID		53371	11130
HPRD ID		06352	18366
Ensembl ID		ENSG00000138750	ENSG00000122952
Uniprot IDs		A0A8Q3SHX2 A0A8Q3WLP2 Q7Z3B4	O95229
PDB IDs		4JNU 4JNV 4JO7 4JO9 5IJN 5IJO 7N8R 7PER 7R5J 7R5K	8PPR
Enriched GO Terms of Interacting Partners?		Cytoskeleton Cytoskeleton-dependent Cytokinesis Centrosome Organelle Assembly Cell Division Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Establishment Of Protein Localization Membrane Fission Microtubule-based Process Intracellular Protein Transport Nuclear Import Signal Receptor Activity Organelle Organization Protein Transport Mitotic Cytokinesis Cytosol Spindle Cellular Localization Chromosome Localization Spindle Pole Regulation Of Microtubule-based Process Nuclear Pore Protein Binding Nuclear Pore Central Transport Channel Membraneless Organelle Assembly Keratin Filament Mitotic Spindle Organization Positive Regulation Of Protein Localization To Centrosome Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Microtubule Polymerization Or Depolymerization Hsp90 Protein Binding Metaphase/anaphase Transition Of Cell Cycle HAUS Complex Regulation Of Sister Chromatid Segregation Vesicle Tethering Involved In Exocytosis Intracellular Protein Localization Mitotic Metaphase Chromosome Alignment Organelle Localization NLS-dependent Protein Nuclear Import Complex Centrosome Cycle Regulation Of Mitotic Nuclear Division Protein Import Into Nucleus Establishment Of Protein Localization To Organelle Intracellular Transport Protein Localization To Organelle Import Into Nucleus Clathrin Adaptor Complex Regulation Of Protein Localization To Centrosome Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Chromosome Segregation	Outer Kinetochore Positive Regulation Of Amyloid Fibril Formation Cell Division Mitotic Sister Chromatid Segregation Chromosome Segregation Sister Chromatid Segregation Skeletal Muscle Satellite Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore MIS12/MIND Type Complex Chromosome, Centromeric Region Nuclear Chromosome Segregation Kinetochore Organelle Organization Skeletal Muscle Cell Proliferation Establishment Of Localization In Cell Intracellular Transport Segment Specification Kinetochore Organization Regulation Of Amyloid Fibril Formation Regulation Of Amyloid-beta Clearance Nucleus Attachment Of Mitotic Spindle Microtubules To Kinetochore Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Chromosome Organization Cellular Localization Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Protein Transport Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Spindle Pole Mitotic Cell Cycle Positive Regulation Of Endocytosis Establishment Of Mitotic Spindle Orientation Positive Regulation Of Nitric Oxide Biosynthetic Process Cellular Developmental Process Positive Regulation Of Nitric Oxide Metabolic Process Establishment Of Mitotic Spindle Localization Negative Regulation Of Mitotic Nuclear Division Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Establishment Of Integrated Proviral Latency T Cell Differentiation In Thymus Establishment Of Spindle Orientation
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