NUP54 and OIP5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NUP54	OIP5
Description		nucleoporin 54	Opa interacting protein 5
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Membrane Nuclear Membrane Nuclear Pore Central Transport Channel	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Chromocenter Cajal Body Nuclear Speck CENP-A Recruiting Complex
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore	Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport Protein Localization To Nuclear Inner Membrane MRNA Transport	Chromosome Segregation Cell Communication CENP-A Containing Chromatin Assembly Cell Division Pericentric Heterochromatin Organization
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Hippocampal volume ( 29274321)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Ulcerative colitis ( 28067908)
Interacting Genes		46 interacting genes: AGR2 AIRIM AP1B1 AP2B1 APC BPIFA1 C14orf119 C21orf91 CCDC85B CCHCR1 CDC23 CENPH DCTN3 DGCR6 EFHC1 EIF3F EXOC1 EXOC8 HAUS1 HAUS8 HGS IFT20 KPNA1 KPNB1 KRT15 KRT27 KRT33B NFKBID NR3C1 NUP62 NUTF2 OGT OIP5 PKNOX2 SMYD3 SOHLH1 SPG21 SSR1 TACC3 TCHP TEKT1 TEX12 TPM3 TRIM54 VPS37C ZWINT	142 interacting genes: A1CF ABI2 ABI3 ABL2 AGXT BCAS2 BEX2 BFSP2 BLOC1S5 BRAF C1orf94 C21orf91 C7orf57 CASP10 CBY2 CCDC22 CCDC24 CCHCR1 CDR2L CEP57 CERK CHCHD2 CIMIP1 COX5B CRACR2A CTNNA3 DMRT3 DTNBP1 DTX2 DUSP21 EFHC1 EIF4ENIF1 ESS2 FAM161B FAM222B FOXJ1 FSD2 GADD45GIP1 GCC1 GEM GLIS2 GPANK1 GPS2 HAPLN2 HGS HJURP HOXB5 HOXB9 HOXC8 HSF4 IL16 KANK2 KDM1A KIF9 KLHL38 KLHL42 KNSTRN KRT14 KRT15 KRT27 KRT3 KRT35 KRT37 KRT40 KRT6B KRT75 KRT81 KRT83 KRT86 KRTAP13-2 KRTAP19-5 KRTAP19-6 LENG1 MECOM MED4 MEIS2 MGAT5B MIIP MIS18A MIS18BP1 MISP MORN3 MYEF2 MYRIP NDUFAB1 NECAB2 NUP54 NUP62 P4HA3 PATZ1 PEX19 PHETA1 PITX2 PLAGL2 POLR2J POU6F2 PRR35 PSMB1 RAB26 RABGEF1 RAF1 RARG RIBC1 RUNX1T1 RUSC1 S100Z SAMD7 SAXO1 SAXO4 SHISA6 SKIL SMARCE1 SNRNP25 SNRPB SOHLH1 SORBS3 SPATA24 SPMIP4 SYCE1L TEKT3 TEX12 TFAP2D TFIP11 TIMM8A TLX3 TMPO TPM3 TPRX1 TRIB3 TRIM73 TRIP6 TROAP TSSK3 USHBP1 USP2 USP54 WASHC1 YTHDF1 ZIC1 ZMAT1 ZNF417 ZNF655
Entrez ID		53371	11339
HPRD ID		06352	09352
Ensembl ID		ENSG00000138750	ENSG00000104147
Uniprot IDs		A0A8Q3SHX2 A0A8Q3WLP2 Q7Z3B4	O43482
PDB IDs		4JNU 4JNV 4JO7 4JO9 5IJN 5IJO 7N8R 7PER 7R5J 7R5K	7SFY
Enriched GO Terms of Interacting Partners?		Cytoskeleton Cytoskeleton-dependent Cytokinesis Centrosome Organelle Assembly Cell Division Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Establishment Of Protein Localization Membrane Fission Microtubule-based Process Intracellular Protein Transport Nuclear Import Signal Receptor Activity Organelle Organization Protein Transport Mitotic Cytokinesis Cytosol Spindle Cellular Localization Chromosome Localization Spindle Pole Regulation Of Microtubule-based Process Nuclear Pore Protein Binding Nuclear Pore Central Transport Channel Membraneless Organelle Assembly Keratin Filament Mitotic Spindle Organization Positive Regulation Of Protein Localization To Centrosome Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Microtubule Polymerization Or Depolymerization Hsp90 Protein Binding Metaphase/anaphase Transition Of Cell Cycle HAUS Complex Regulation Of Sister Chromatid Segregation Vesicle Tethering Involved In Exocytosis Intracellular Protein Localization Mitotic Metaphase Chromosome Alignment Organelle Localization NLS-dependent Protein Nuclear Import Complex Centrosome Cycle Regulation Of Mitotic Nuclear Division Protein Import Into Nucleus Establishment Of Protein Localization To Organelle Intracellular Transport Protein Localization To Organelle Import Into Nucleus Clathrin Adaptor Complex Regulation Of Protein Localization To Centrosome Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Chromosome Segregation	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Keratin Filament Protein Binding Supramolecular Fiber Organization Cytoskeleton Axonemal A Tubule Inner Sheath Cytoskeleton Organization Structural Molecule Activity Organelle Organization Sperm Flagellum Keratinization Motile Cilium CENP-A Containing Chromatin Assembly Pericentric Heterochromatin Organization CENP-A Recruiting Complex
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